NDLI: Indentation Determined Mechanoelectrochemical Properties and Fixed Charge Density of Articular Cartilage

Content Provider	Springer Nature Link
Author	Lu, X. Lux Sun, Daniel D. N. Guo, X. Edward Chen, Faye H. Lai, W. Michael Mow, Van C.
Copyright Year	2004
Abstract	As a nondestructive technique, the indentation test has been used, both in vitro and in vivo, to determine the in situ apparent mechanical properties of cartilage. In this study, a simple new algorithm was developed using the indentation creep test, combined with both biphasic and triphasic analyses to calculate simultaneously the apparent and intrinsic mechanical (aggregate modulus and Poisson's ratio) and an electrochemical properties, i.e., the fixed charge density (FCD) of the intact articular cartilage. The calculated FCD values were compared with those measured using the biochemical assay of the proteoglycan content in the tissue. It was found: (1) the FCDs obtained from this new indentation method (0.287± 0.157 mEq/ml) were significantly correlated with the results from biochemical assay; (2) significantly positive linear relationships existed between the intrinsic and apparent mechanical moduli; (3) both the apparent and intrinsic mechanical properties correlated significantly with the proteoglycan content in the cartilage specimen. These results suggest two distinct interaction mechanisms between the collagen network and the proteoglycans in cartilage layer. The proteoglycans contribute to the mechanical properties of articular cartilage not only by the Donnan osmotic pressure induced by the fixed charges, but also by its bulk mass. Current study represents a first step toward developing a valid and effective method for the study of structure–function relationship in cartilage and possibly for future early stage OA detection in vivo.
Starting Page	370
Ending Page	379
Page Count	10
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	32
Issue Number	3
e-ISSN	15739686
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2004-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Biochemistry Mechanics Biophysics/Biomedical Physics Vibration, Dynamical Systems, Control Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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