NDLI: Noninvasive Characterization of Vascular Tone by Model-Based System Identification in Healthy and Heart Failure Patients

Content Provider	Springer Nature Link
Author	Zheng, Ya Li Yan, Bryan P. Zhang, Yuan Ting Poon, Carmen C. Y.
Copyright Year	2015
Abstract	Current markers for heart failure (HF) diagnosis and prognosis are mainly for the evaluation of cardiac functions. Since previous studies have reported that HF patients demonstrated abnormal vascular responses to external stimuli, it is speculated that vascular tone, a measure of activation level of vascular wall, may be able to reflect these abnormalities to assist HF detection. Nevertheless, vascular tone is difficult to be objectively quantified using existing tools. In this study, a vascular tone index was estimated from noninvasive blood pressure and pulse transit time measurements using system identification technique. This method was evaluated in 35 subjects (10 healthy, 13 with HF risk factors and 12 HF patients) in a regular maximal exercise test. It was found that the vascular tone index significantly increased by 24.4 ± 26.6% (p < 0.01) during maximal exercise in the healthy subjects. Moreover, the response was gradually attenuated in the risk-factor and HF groups (15.8 ± 36.5 and 0.9 ± 17.9%, respectively). The results reveal the association between the vascular tone response to maximal exercise and HF disease or risks. To conclude, the proposed method provides a quantitative characterization of vascular tone which may be a useful indicator of the pathological changes of the arteries or the heart.
Starting Page	2242
Ending Page	2252
Page Count	11
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	43
Issue Number	9
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2015-02-04
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Computational biology Personalized medicine p-Health Public health informatics Pulse transit time Subject-specific monitoring Biomedicine general Biomedical Engineering Biophysics and Biological Physics Mechanics Biochemistry
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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