NDLI: Surfactant Properties Differentially Influence Intravascular Gas Embolism Mechanics

Content Provider	Springer Nature Link
Author	Swaminathan, T. N. Ayyaswamy, P. S. Eckmann, D. M.
Copyright Year	2010
Abstract	Gas bubble motion in a blood vessel causes temporal and spatial gradients of shear stress at the cell surface lining the vessel wall as the bubble approaches the cell, moves over it and passes it by. Rapid reversals occur in the sign of the shear stress imparted to the cell surface during this motion. These may result in injury to the cell. The presence of a soluble surfactant in the bulk medium reduces the level of the shear stress gradients imparted to the cell surface as compared to an equivalent surfactant-free system and is an important therapeutic aid. This is particularly true for a very small vessel. In this study, we analyze various physical and chemical properties of any given soluble surfactant to ascertain the relative significance of the property of the surfactant on the reduction in the level of the shear stress gradients imparted to the cell surface in such a vessel. While adsorption, desorption, and maximum possible monolayer interface surfactant concentration significantly impact the shear stress levels, physical properties such as the bulk or surface diffusivity do not appear to have large effects. At a given diameter, surfactants with $$k_{\rm a}/(k_{\rm d} d) >{{\mathcal{O}}}(10^{-5})$$ and $${Γ_\infty/C_0d}\,>\,9.5 \times 10^{-4}$$ are noted to be preferable from the point of view of an increased gap size between the bubble and vessel wall, and a corresponding reduction in the shear stress level imparted to an endothelial cell. The shear stress characteristics of nearly occluding bubbles, in contrast with smaller sized bubbles under identical conditions, are most affected by the introduction of a surfactant in regard to shear stress levels. These observations could form a basis for choosing surfactants in treating gas embolism related illnesses.
Starting Page	3649
Ending Page	3663
Page Count	15
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	38
Issue Number	12
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2010-07-13
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Finite-sized bubble motion Blood vessel Soluble surfactant Biochemistry Mechanics Biophysics and Biological Physics Biomedical Engineering Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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