NDLI: Low Stress Tendon Fatigue is a Relatively Rapid Process in the Context of Overuse Injuries

Content Provider	Springer Nature Link
Author	Parent, Gabriel Huppé, Nicolas Langelier, Eve
Copyright Year	2011
Abstract	To stimulate healing and prevent tendinosis through optimized physical exercise, it is important to elucidate the tendon response to repetitive mechanical loading. However, the study of this response is challenging due to complex cell–matrix interactions. In an initial approximation, the authors examined tendon mechanical response only, and did not consider cellular activity. The authors investigated the hypothesis that mechanical degradation occurs relatively rapidly (<24 h) even at very low stress levels. The authors subjected rat tail tendons to mechanical loadings oscillating between 0 and 1.5 MPa up to one of three fatigue levels: 4% strain, 8% strain, or rupture. Using non-destructive mechanical tests, changes in tendon strain and compliance over the entire fatigue testing period were evaluated. Using microscopy techniques, the structural evidence of mechanical degradation was examined. The changes in tendon strain and compliance progressed nonlinearly and accelerated before rupture which took place around the 15-h mark. Histological analyses revealed a higher degree of alteration in the collagen network at increased fatigue levels. At rupture, local zones of damage with low fibril density were evident. These results imply that a repair process must act rapidly at critical sites; otherwise, enzymatic degradation could cause further damage in the manner of a vicious cycle.
Starting Page	1535
Ending Page	1545
Page Count	11
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	39
Issue Number	5
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2011-02-02
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Mechanical degradation Biomechanics Strain Compliance Histology Biochemistry Mechanics Biomedical Engineering Biomedicine general Biophysics and Biological Physics
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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