NDLI: The effect of aneurismal-wall mechanical properties on patient-specific hemodynamic simulations: two clinical case reports

Content Provider	Springer Nature Link
Author	Chen, Jialiang Wang, Shengzhang Ding, Guanghong Yang, Xinjian Li, Haiyun
Copyright Year	2009
Abstract	Hemodynamic factors such as the wall shear stress play an important role in the pathogenesis and treatment of cerebral aneurysms. In present study, we apply computational fluid–structure interaction analyses on cerebral aneurysms with two different constitutive relations for aneurismal wall in order to investigate the effect of the aneurismal wall mechanical properties on the simulation results. We carry out these analyses by using two patient-specific models of cerebral aneurysms of different sizes located in different branches of the circle of Willis. The models are constructed from 3D rotational angiography image data and blood flow dynamics is studied under physiologically representative waveform of inflow. From the patient models analyzed in this investigation, we find that the deformations of cerebral aneurysms are very small. But due to the nonlinear character of the Navier–Stokes equations, these small deformations could have significant influences on the flow characteristics. In addition, we find that the aneurismal-wall mechanical properties have great effects on the deformation distribution of the aneurysm, which also affects the wall shear stress distribution and flow patterns. Therefore, how to define a proper constitutive relation for aneurismal wall should be considered carefully in the hemodynamic simulation.
Starting Page	677
Ending Page	688
Page Count	12
File Format	PDF
ISSN	05677718
Journal	Acta Mechanica Sinica
Volume Number	25
Issue Number	5
e-ISSN	16143116
Language	English
Publisher	Springer-Verlag
Publisher Date	2009-05-16
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Intracranial aneurysm Fluid–structure interaction Computational fluid dynamics Hemodynamics Computational Intelligence Engineering Fluid Dynamics Classical Continuum Physics Theoretical and Applied Mechanics
Content Type	Text
Resource Type	Article
Subject	Mechanical Engineering Computational Mechanics

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