NDLI: Microvalve and liquid membrane double-controlled integrated microfluidics for observing the interaction of breast cancer cells

Content Provider	Springer Nature Link
Author	Liu, Ajing Liu, Wenming Wang, Yaolei Wang, Jian Chun Tu, Qin Liu, Rui Xu, Juan Shen, Shaofei Wang, Jinyi
Copyright Year	2012
Abstract	The methodical development of cell biology has resulted in significant advancements in the study of breast tumors. However, the dynamic investigation of the self-seeding process remains largely out of reach. In the present study, we describe a microvalve and liquid membrane double-controlled integrated microfluidic device that provides for the versatile assessment of breast tumor cell invasion dynamics. The liquid membrane formation was first optimized to obtain a high level of control, and was then applied to different types of homotypic and heterotypic cell seeding with precise selective positioning for monoculture and coculture. Using this device, the interaction between breast cancer cells MDA231-LM2 and MDA-MB231 was successfully observed to investigate self-seeding dynamics, including migration, infiltration, and coexistence. The results quantitatively demonstrate the mutual signal-induced attraction between MDA-MB231 and MDA231-LM2 cells, as well as the progressive infiltration of MDA231-LM2 cells into the MDA-MB231 cell population. These results are valuable in the development of spatiotemporal-controlled microfluidic systems and to many microscale-based biological and diagnostic studies involving cell growth, cell differentiation, cell interaction, and cell signal.
Starting Page	515
Ending Page	526
Page Count	12
File Format	PDF
ISSN	16134982
Journal	Microfluidics and Nanofluidics
Volume Number	14
Issue Number	3-4
e-ISSN	16134990
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-10-14
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Microvalve Liquid membrane Integrated microfluidics Breast cancer cells Interaction Engineering Fluid Dynamics Biomedical Engineering Analytical Chemistry Nanotechnology and Microengineering
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Materials Chemistry Condensed Matter Physics Electronic, Optical and Magnetic Materials

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