NDLI: Microfluidics analysis of nanoparticle mixing in a microchannel system

Content Provider	Springer Nature Link
Author	Li, Jie Kleinstreuer, Clement
Copyright Year	2008
Abstract	The microfluidics of controlled nanodrug delivery to living cells in a representative, partially heated microchannel was analyzed, using a validated computer model. The objective was to achieve uniform nanoparticle exit concentrations at a minimum microchannel length with the aid of simple static mixers, e.g., a multi-baffle-slit or perforated injection micro-mixer. A variable wall heat flux, which influences the local nanofluid properties and carrier-fluid velocities, was added to ensure that mixture delivery to the living cells occurred at the required (body) temperature of 37°C. The results show that both the baffle-slit micro-mixer and the perforated injection micro-mixer aid in decreasing the microchannel length while achieving uniform nanoparticle exit concentrations. The injection micro-mixer not only decreases best the system’s dimension, but also reduces the system power requirement. The baffle-slit micro-mixer also decreases the microchannel length; however, it may add to the power requirement. The imposed wall heat flux aids in enhanced nanoparticle and base-fluid mixing as well.
Starting Page	661
Ending Page	668
Page Count	8
File Format	PDF
ISSN	16134982
Journal	Microfluidics and Nanofluidics
Volume Number	6
Issue Number	5
e-ISSN	16134990
Language	English
Publisher	Springer-Verlag
Publisher Date	2008-09-02
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Microfluidics Nanofluid Micro-mixer Heat and mass transfer Nanodrug delivery Biomedical Engineering Engineering Fluid Dynamics
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Materials Chemistry Condensed Matter Physics Electronic, Optical and Magnetic Materials

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