NDLI: Systematic linearisation of a microfluidic gradient network with unequal solution inlet viscosities demonstrated using glycerol

Content Provider	Springer Nature Link
Author	Yusuf, Hayat Abdulla Baldock, Sara J. Fielden, Peter R. Goddard, Nick J. Mohr, Stephan Treves Brown, Bernard J.
Copyright Year	2009
Abstract	This paper presents a mathematical and experimental study of the effect of inlet concentration (and therefore viscosity) of glycerol solutions on the performance of a microfluidic network. This was achieved with analytical modelling, implemented in MATLAB, and optical measurement of the entire concentration distribution of the network. A mathematical proposal to improve the linearity of the outlet profile is also implemented and successfully verified experimentally. The concentration gradients of a two inlet–six outlet (2–6) microfluidic network device were obtained with inlet solutions of 10–40 wt% glycerol and flow rates of up to 5 μl/s per inlet. The mathematical model developed gave a good agreement with the experimental results obtained. ‘S’ shaped outlet profiles were obtained for the four glycerol cases studied and the closest results to the model were achieved at an optimised flow rate of 1μl/s for 10 wt% glycerol, 5 μl/s for both 20 and 30 wt% glycerol and 1.5 μl/s for 40 wt% glycerol. The linearity of the outlet profiles for the 20, 30 and 40 wt% inlet glycerol experiments were improved from R 2 of 0.977, 0.946 and 0.966, respectively (before linearisation) to their new values of 0.997, 0.995 and 0.974, respectively (after the linearisation). This was performed by application of the mathematical model, at controlled inlet flow rate ratios of 0.77, 0.63 and 0.52 with respect to the viscous inlet, for 20, 30 and 40 wt% glycerol experiments, again with very good agreement of the outlet performance between the experimental and the mathematical results.
Starting Page	587
Ending Page	598
Page Count	12
File Format	PDF
ISSN	16134982
Journal	Microfluidics and Nanofluidics
Volume Number	8
Issue Number	5
e-ISSN	16134990
Language	English
Publisher	Springer-Verlag
Publisher Date	2009-09-04
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Linear concentration gradient Viscous inlets Glycerol Optical detection Microfluidic device Microfabrication Biomedical Engineering Engineering Fluid Dynamics
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Materials Chemistry Condensed Matter Physics Electronic, Optical and Magnetic Materials

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