NDLI: Modular membrane valves for universal integration within thermoplastic devices

Content Provider	Springer Nature Link
Author	Toh, Alicia G. G. Wang, Zhiping Wang, Zhenfeng
Copyright Year	2016
Abstract	While much research has been conducted on elastomeric valves within PDMS microfluidic devices, we rarely see scalable manufacturing processes for integrating such valves into rigid thermoplastic devices. Most thermoplastic materials do not share intrinsic bonding compatibility to flexible elastomer membranes, making it difficult to ensure leak-proof operation of such valves within thermoplastic devices. In order to overcome bonding compatibility issues, we propose decoupling the valve architecture from the fluidic routing device layers. This can be achieved by prefabricating modular valves via molding processes and subsequently inserting them into thermoplastic layers containing valve seats. Thermoplastic layers containing modular valves are then thermally bonded to thermoplastic layers containing the fluidic routing channels, resulting in leak-proof valve integration. At valve actuation pressures of approximately 60 kPa, the modular membrane valves seal fluidic channels operating at a flow rate of 100 µl min−1. Modular valves that were incorporated into a concentration gradient generator demonstrated dynamically configurable fluid routing at a response frequency of 5 Hz. The integration of modular membrane valves is an effective solution to streamline and cost-down the manufacturing of hybrid elastomer–thermoplastic devices. As this solution does not rely on bonding compatibility between the elastomeric membranes and the thermoplastic device, it can be applied universally to solve integration issues for low-cost thermoplastic device fabrication.
Starting Page	1
Ending Page	9
Page Count	9
File Format	PDF
ISSN	16134982
Journal	Microfluidics and Nanofluidics
Volume Number	20
Issue Number	6
e-ISSN	16134990
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-05-26
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Microfluidics Valves Thermoplastic Gradient generator Engineering Fluid Dynamics Biomedical Engineering Analytical Chemistry Nanotechnology and Microengineering
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Materials Chemistry Condensed Matter Physics Electronic, Optical and Magnetic Materials

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Optimization and development of a universal flow-based microfluidic gradient generator

Novel prototyping method for microfluidic devices based on thermoplastic polyurethane microcapillary film

Single-use thermoplastic microfluidic burst valves enabling on-chip reagent storage

An integrated microfluidic signal generator using multiphase droplet grating

Microfluidic bolus induced gradient generator for live cell signalling

Fabrication of layered polydimethylsiloxane/perfluoropolyether microfluidic devices with solvent compatibility and valve functionality

Special issue on magnetic-based microfluidics

Engineering microfluidic concentration gradient generators for biological applications

Review on miniaturized paraffin phase change actuators, valves, and pumps

Modular membrane valves for universal integration within thermoplastic devices

Similar Documents

Optimization and development of a universal flow-based microfluidic gradient generator

Novel prototyping method for microfluidic devices based on thermoplastic polyurethane microcapillary film

Single-use thermoplastic microfluidic burst valves enabling on-chip reagent storage

An integrated microfluidic signal generator using multiphase droplet grating

Microfluidic bolus induced gradient generator for live cell signalling

Fabrication of layered polydimethylsiloxane/perfluoropolyether microfluidic devices with solvent compatibility and valve functionality

Special issue on magnetic-based microfluidics

Engineering microfluidic concentration gradient generators for biological applications

Review on miniaturized paraffin phase change actuators, valves, and pumps

Modular membrane valves for universal integration within thermoplastic devices