NDLI: A miniaturized flow reaction chamber for use in combination with QCM-D sensing

Content Provider	Springer Nature Link
Author	Ohlsson, Gabriel Axelsson, Pauline Henry, Joshua Petronis, Sarunas Svedhem, Sofia Kasemo, Bengt
Copyright Year	2010
Abstract	A miniaturized flow chamber for quartz crystal microbalance with dissipation monitoring (QCM-D) has been developed. The main purpose was to reduce the total liquid sample consumption during an experiment, but also to gain advantages with respect to kinetics and mass transport by reducing the boundary diffusion layer. The bottom of the flow chamber is a QCM-D sensor surface, on which a polydimethylsiloxane spacer ring, fabricated onto a poly(methyl methacrylate) lid, is placed symmetrically around the QCM-D electrode (diameter ~10 mm). The spacer ring defines the inner chamber height (typically 40–50 μm) and provides sealing. Through the lid, there are inlet and outlet channels. The typical chamber volume is in the range of 2.5–3.5 μl (with a 10 μl dead volume). In flow mode, we have operated the cell at flow rates of 6–50 μl/min, i.e., volume turnovers of 2–17 per min. As a model system, to test the microcell, the formation of supported phospholipid bilayers on a SiO2 surface was studied. For comparison, the same process was studied in a commercially available QCM-D equipment with significantly larger total volume (by a factor of 20). The decrease in effective sample consumption to produce a bilayer on the sensor surface in the chamber was approximately proportional to the decrease in chamber volume. Smaller volume also reduced the liquid exchange time. Potential improvements of the chamber include further optimization of the flow profile and, in addition, further miniaturization by decreasing the chamber height and the sensor radius.
Starting Page	705
Ending Page	716
Page Count	12
File Format	PDF
ISSN	16134982
Journal	Microfluidics and Nanofluidics
Volume Number	9
Issue Number	4-5
e-ISSN	16134990
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-03-06
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Miniaturized flow chamber Biosensor QCM-D Supported lipid bilayers Boundary layer diffusion Biomedical Engineering Industrial Chemistry/Chemical Engineering Engineering Fluid Dynamics
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Materials Chemistry Condensed Matter Physics Electronic, Optical and Magnetic Materials

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Hydrodynamic dispersion in long microchannels under conditions of electroosmotic circulation. I. Non-electrolytes

Formation of vortices in long microcavities at low Reynolds number

Mixing in an enclosed microfluidic chamber through moving boundary motions

Phenomena peculiar to underexpanded flows in supersonic micronozzles

Miniaturized flow cytometer with 3D hydrodynamic particle focusing and integrated optical elements applying silicon photodiodes

Boundary layer analysis and heat transfer of a nanofluid

QCM-D studies of human norovirus VLPs binding to glycosphingolipids in supported lipid bilayers reveal strain-specific characteristics

Molecular dynamics simulation on flow behavior of nanofluids between flat plates under shear flow condition

Effect of the skimming layer on electro-osmotic—Poiseuille flows of viscoelastic fluids

A miniaturized flow reaction chamber for use in combination with QCM-D sensing

Similar Documents

Hydrodynamic dispersion in long microchannels under conditions of electroosmotic circulation. I. Non-electrolytes

Formation of vortices in long microcavities at low Reynolds number

Mixing in an enclosed microfluidic chamber through moving boundary motions

Phenomena peculiar to underexpanded flows in supersonic micronozzles

Miniaturized flow cytometer with 3D hydrodynamic particle focusing and integrated optical elements applying silicon photodiodes

Boundary layer analysis and heat transfer of a nanofluid

QCM-D studies of human norovirus VLPs binding to glycosphingolipids in supported lipid bilayers reveal strain-specific characteristics

Molecular dynamics simulation on flow behavior of nanofluids between flat plates under shear flow condition

Effect of the skimming layer on electro-osmotic—Poiseuille flows of viscoelastic fluids

A miniaturized flow reaction chamber for use in combination with QCM-D sensing