NDLI: Multiple cyst formation in the liver and kidneys of a lion (Panthera leo): a case of polycystic kidney disease?

Content Provider	Springer Nature Link
Author	Gerhauser, Ingo Philipp, Ute Distl, Ottmar Beineke, Andreas
Copyright Year	2009
Abstract	The present report describes the case of a 19-year-old male lion (Panthera leo) with polycystic lesions in liver and kidney. The animal suffered from inappetence and progressing hind limb weakness and was euthanized due to poor prognosis. Necropsy revealed multiple large, cystic cavities in the liver and numerous cysts in the renal cortex. Hepatic and renal cysts were lined by a flattened or cuboidal single-layered epithelium and derived from hepatic bile ducts and renal tubular structures, respectively, as confirmed by immunohistochemistry for the detection of different cytokeratins and carcinoembryonic antigen. Furthermore, a marked bile duct proliferation and fibrosis was found in the portal areas. Occasionally, renal cysts contained variable amounts of partly mineralized proteinaceous material, detached epithelial cells, and cellular debris. Additional findings included a moderate suppurative bronchopneumonia and other minor age-related degenerative changes. A mutation screen of exon 29 of the PKD1 gene did not reveal causative mutations like in domestic cats. This is the first report of polycystic kidney disease (PKD)-like lesions in a lion. The features of these lesions are similar to those of the adult-onset form of PKD in Persian cats.
Starting Page	433
Ending Page	437
Page Count	5
File Format	PDF
ISSN	16124642
Journal	European Journal of Wildlife Research
Volume Number	55
Issue Number	4
e-ISSN	14390574
Language	English
Publisher	Springer-Verlag
Publisher Date	2009-03-10
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hepatic cysts Lion Polycystic kidney disease genes Renal cysts Animal Ecology Zoology
Content Type	Text
Resource Type	Article
Subject	Ecology, Evolution, Behavior and Systematics Management, Monitoring, Policy and Law Nature and Landscape Conservation

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