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| Content Provider | Springer Nature Link |
|---|---|
| Author | Lu, Juan Liu, Qingfei Zhao, Xinge Gao, Rong Cong, Wenjuan Wang, Yiming Luo, Guoan |
| Copyright Year | 2010 |
| Abstract | Scutellarin is released from the prodrug Scu-PEG after i.v. administration to rats. To investigate changes in the amount of the prodrug in vivo, a liquid chromatographic method for simultaneous analysis of Scu-PEG and scutellarin in rat plasma was developed and validated. A C18 column was used with a binary mobile phase gradient prepared from acetonitrile and 0.3% aqueous formic acid solution. The detection wavelength was 334 nm and the column temperature 40 °C. Linearity was excellent, with R 2 no less than 0.999. Intra-assay and inter-assay precision, as RSD, were less than 6.4 and 4.7%, respectively, for scutellarin and less than 2.8 and 2.9% for Scu-PEG. The method is applicable to pharmacokinetic study the prodrug and its metabolite in rats after i.v. administration. |
| Starting Page | 511 |
| Ending Page | 515 |
| Page Count | 5 |
| File Format | |
| ISSN | 00095893 |
| Journal | Chromatographia |
| Volume Number | 71 |
| Issue Number | 5-6 |
| e-ISSN | 16121112 |
| Language | English |
| Publisher | Vieweg Verlag |
| Publisher Date | 2010-02-02 |
| Publisher Place | Wiesbaden |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Column liquid chromatography Simultaneous analysis and method validation Scutellarin Scu-PEG prodrug Measurement Science and Instrumentation Plant Sciences Biochemistry Pharmacy Organic Chemistry Analytical Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Analytical Chemistry Biochemistry Clinical Biochemistry |
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