NDLI: Chromatographic Separation of the Enantiomers of a Series of C2-Asymmetric Bi-Naphthyl Compounds by Molecularly Imprinted Polymers

Content Provider	Springer Nature Link
Author	Luo, Yong Liu, Lan Li, Lihong Deng, Qinying
Copyright Year	2006
Abstract	The aim of this study was to observe the chiral separation of a series of C2-asymmetric bi-naphthyl compounds on molecularly imprinted polymers (MIPs) using 1,1′-bi-2-naphthol (BINOL) as template. MIP prepared using 4-vinylpyridine as the functional monomer showed better chiral recognition for the template than the MIPs prepared using acrylamide, 2-(diethylamino)ethylmethacrylate and 2-vinylpyridine, respectively. 1H-NMR was used for comparison of the interactions between template and functional monomers. For chromatographic analysis the effects of mobile phase and temperature on the chiral separation were investigated. When 4-vinylpyridine was employed as the functional monomer, chiral separation of 1,1′-bi-2-naphthol and its analogues were studied. The MIP also demonstrated an ability to discriminate between enantiomers of structurally related compounds that had not been imprinted. The thermodynamic parameters of interactions between substrates and MIP in acetonitrile based mobile phase were investigated by the Van’t Hoff equation. In this study, the specific hydrogen-bonding interactions seemed to be the key factor to achieve chiral separation.
Starting Page	393
Ending Page	397
Page Count	5
File Format	PDF
ISSN	00095893
Journal	Chromatographia
Volume Number	64
Issue Number	7-8
e-ISSN	16121112
Language	English
Publisher	Vieweg Verlag
Publisher Date	2006-08-31
Publisher Place	Wiesbaden
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Column liquid chromatography Molecularly imprinted polymers Chiral separation 1,1′-Bi-2-naphthol 1H-NMR Van’t Hoff equation Measurement Science, Instrumentation Plant Sciences Biochemistry Pharmacy Organic Chemistry Analytical Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Analytical Chemistry Biochemistry Clinical Biochemistry

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