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| Content Provider | Springer Nature Link |
|---|---|
| Author | Kong, Detao Wang, Siting Ling, Xiaomei Li, Runtao Cui, Jingrong |
| Copyright Year | 2009 |
| Abstract | A new, specific and sensitive high performance liquid chromatography analytical procedure was developed and validated for the determination of TM208 in rat primary solid organs/tissues and plasma. TM208 was extracted from the appropriate matrix using methanol followed by centrifugation at 11,255×g for 20 min and injection of a 30 μL aliquot. Separation was carried out under gradient conditions using an ODS C18 column equipped with a guard column. The mobile phase consisted of methanol and water and retention times of TM208 and plunarizine (IS) were 17.658 and 26.175 min, respectively. The analytical procedure provided acceptable precision, accuracy, recoveries and linearity. Stability studies showed that TM208 was stable in organs/tissues homogenates for three freeze–thaw cycles, at room temperature for at least 24 h 3 weeks at −20 °C. The validated method was successfully applied to the determination of TM208 in SD rats following oral administration at a dose of 250 mg kg−1. |
| Starting Page | 1721 |
| Ending Page | 1725 |
| Page Count | 5 |
| File Format | |
| ISSN | 00095893 |
| Journal | Chromatographia |
| Volume Number | 70 |
| Issue Number | 11-12 |
| e-ISSN | 16121112 |
| Language | English |
| Publisher | Vieweg Verlag |
| Publisher Date | 2009-11-05 |
| Publisher Place | Wiesbaden |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Liquid chromatography Dithiocarbamate Rat organs and plasma samples Distribution Measurement Science and Instrumentation Plant Sciences Biochemistry Pharmacy Organic Chemistry Analytical Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Analytical Chemistry Biochemistry Clinical Biochemistry |
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