NDLI: Separation of Clinical Grade 188Re from 188W Using Polymer Embedded Nanocrystalline Titania

Content Provider	Springer Nature Link
Author	Chakravarty, Rubel Dash, Ashutosh Venkatesh, Meera
Copyright Year	2009
Abstract	Currently, 188Re is obtained from 188W/188Re chromatographic generator containing alumina which has a limited capacity (~80 mg Wg−1) for 188W. This results in high bolus volumes of 188Re, which often needs to be concentrated before radiolabeling. We have demonstrated the feasibility of using polymer embedded nano crystalline titania (TiP), a novel high capacity sorbent material (~300 mg Wg−1), for developing a 188W/188Re chromatographic generator. A TiP based chromatographic 188W/188Re generator was developed in which 188Re could be eluted with 0.9% saline solution. About 90% of the 188Re could be recovered in the first 4–5 mL of total activity with more than 80% yield. The purity of 188Re is adequate for clinical applications.
Starting Page	1363
Ending Page	1372
Page Count	10
File Format	PDF
ISSN	00095893
Journal	Chromatographia
Volume Number	69
Issue Number	11-12
e-ISSN	16121112
Language	English
Publisher	Vieweg Verlag
Publisher Date	2009-03-22
Publisher Place	Wiesbaden
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Inductively plasma-atomic emission spectroscopy Polymer embedded nanocrystalline titania 188W/188Re chromatographic generator Radiochemical and radionuclidic purity Measurement Science, Instrumentation Plant Sciences Biochemistry Pharmacy Organic Chemistry Analytical Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Analytical Chemistry Biochemistry Clinical Biochemistry

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