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| Content Provider | Springer Nature Link |
|---|---|
| Author | Mikšík, Ivan Sedláková, Pavla Pataridis, Statis Bortolotti, Federica Gottardo, Rossella Tagliaro, Franco |
| Copyright Year | 2014 |
| Abstract | The natural mummy of prince Cangrande, Lord of Verona, Italy (1291–1329 AD) was studied. Two samples were taken: rib bone and muscle. These samples were cleaved with trypsin and analysed by liquid chromatographic methods coupled to mass spectrometry (Q-TOF, ion-trap). Special attention was devoted to nonenzymatic protein modification––the deamidation of asparagine and glutamine. A huge amount of collagen was determined in the tissues of the mummy (covering over 80 % of the sequence)––collagen type I was identified in the rib bone and collagen types I and III in the muscle. A high overall percentage of asparaginyl and glutaminyl residues were deamidated (up to 92 %). In agreement with the literature we can suppose that the deamidation of really old samples (at least 100-years-old) is mainly dependent on the burial conditions and/or thermal age and cannot serve as a precise “molecular clock”. |
| Starting Page | 1503 |
| Ending Page | 1510 |
| Page Count | 8 |
| File Format | |
| ISSN | 00095893 |
| Journal | Chromatographia |
| Volume Number | 77 |
| Issue Number | 21-22 |
| e-ISSN | 16121112 |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2014-06-28 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Column liquid chromatography, Mass spectrometry Collagen Deamidation Mummy Protein modification Chromatography Proteomics Pharmacy Laboratory Medicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Analytical Chemistry Biochemistry Clinical Biochemistry |
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