NDLI: Chemical Fingerprinting of Medicinal Plants “Gui-jiu” by LC-ESI Multiple-Stage MS

Content Provider	Springer Nature Link
Author	Zhou, Yan Jiang, Shun Yuan Ding, Li Sheng Cheng, Sau Wan Xu, Hong Xi But, Paul Pui Hay Shaw, Pang Chui
Copyright Year	2008
Abstract	The rhizomes or roots of Dysosma versipellis (Hance) M. Cheng, Dysosma pleiantha (Hance) Woodson, and Sinopodophyllum emodi (Wall. Ex Royle) Ying under the same name “Gui-jiu”, were widely used for medicinal purposes. Valid quality control of Gui-jiu is desirable due to the fact that they are highly toxic. In the present paper, an accurate fingerprint method was developed to identify the three species. Liquid chromatography coupled with photodiode array detection and electrospray ionization-multiple stage mass spectrometry were developed to identify the fingerprint components. According to the characteristic fragmentation behavior of known lignans and flavonoids isolated from D. versipellis, a total of 15 constituents in the crude extracts were structurally characterized on the basis of retention time, UV and tandem mass spectrometric analysis. Eight batches of D. versipellis, three batches of D. pleiantha, and two batches of S. emodi were collected from different locations and these representative samples reflected the similar chemical constituent properties. The extracts were separated by a C18 reversed phase LC column, with a gradient solvent system. The proposed method provides a scientific and technical platform to the herbal industry for quality control and safety assurance of herbal preparations that contain this class of poisonous podophyllotoxin-type lignans.
Starting Page	781
Ending Page	789
Page Count	9
File Format	PDF
ISSN	00095893
Journal	Chromatographia
Volume Number	68
Issue Number	9-10
e-ISSN	16121112
Language	English
Publisher	Vieweg Verlag
Publisher Date	2008-08-30
Publisher Place	Wiesbaden
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Liquid chromatography-mass spectrometry Electrospray ionization-multiple stage mass spectrometry Chemical fingerprinting Dysosma versipellis, Dysosma pleiantha and Sinopodophyllum emodi Measurement Science, Instrumentation Plant Sciences Biochemistry Pharmacy Organic Chemistry Analytical Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Analytical Chemistry Biochemistry Clinical Biochemistry

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