NDLI: Quantitative and selective analysis of lactose by capillary electrophoresis

Content Provider	Springer Nature Link
Author	Altria, K. Ennis, K. Sadler, R.
Copyright Year	1998
Abstract	A CE method has been validated for the analysis of batches of lactose used as a pharmaceutical raw material. This method was shown to be selective for lactose and was found to be quantitative. The separation was achieved due to on-capillary chelation of the lactose with borate ion. The resulting complex was detected at 195nm. An internal standard is employed to improve injection precision and detector linearity. A system peak occurred in the separation and was systematically investigated to show that it was not sample related. The method was validated and successfully submitted to regulatory authorities and is now in routine use in a number of our quality control laboratories.
Starting Page	406
Ending Page	410
Page Count	5
File Format	PDF
ISSN	00095893
Journal	Chromatographia
Volume Number	49
Issue Number	7-8
e-ISSN	16121112
Language	English
Publisher	Vieweg Verlag
Publisher Date	1998-01-01
Publisher Place	Wiesbaden
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Capillary electrophoresis Pharmaceutical Analysis Lactose Analytical Chemistry Organic Chemistry Pharmacy Biochemistry Plant Sciences Measurement Science, Instrumentation
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Analytical Chemistry Biochemistry Clinical Biochemistry

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Quantitative and selective analysis of lactose by capillary electrophoresis