NDLI: Determination and comparison of competitive isotherms by frontal analysis and frontal velocity analysis

Content Provider	Springer Nature Link
Author	Burger, D. Neumüller, R. Yang, G. L. Engelhardt, H. Quiñones, I. Guiochon, G.
Copyright Year	2000
Abstract	The competitive isotherms of the two enantiomers of oxazepam on two chiral stationary phases differing by the surface concentration of the chiral selector were derived from adsorption data measured with only the racemic mixture. Sample solubility problems limited the range of concentrations within which the measurements were possible. Slow racemization of oxazepam at room temperature prevented the use of any other sample composition than that of the racemic mixture. Two different approaches, the conventional binary frontal analysis method and the new frontal velocity method were applied for the determination of these competitive isotherms. Both sets of experimental data were found to fit well to the competitive-Langmuir isotherm equation. The best coefficients obtained with the two methods were close. The frontal velocity method has the advantages of a greater experimental simplicity, of being faster, and of requiring a smaller amount of material to acquire the necessary data. It may suffer, however, from the possibility of a systematic drift of the isotherm data due to cumulative errors.
Starting Page	517
Ending Page	525
Page Count	9
File Format	PDF
ISSN	00095893
Journal	Chromatographia
Volume Number	51
Issue Number	9-10
e-ISSN	16121112
Language	English
Publisher	Vieweg Verlag
Publisher Date	2000-01-01
Publisher Place	Wiesbaden
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Column liquid chromatography Competitive isotherm measurement Mass balance Frontal velocity analysis Enantiomeric separation Analytical Chemistry Organic Chemistry Pharmacy Biochemistry Plant Sciences Measurement Science, Instrumentation
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Analytical Chemistry Biochemistry Clinical Biochemistry

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