NDLI: Criteria in Chromatography and Mass Spectrometry – a Comparison Between Regulations in the Field of Residue and Doping Analysis

Content Provider	Springer Nature Link
Author	Van Eeo, P. Delbeke, F. T.
Copyright Year	2004
Abstract	Residue analysis and doping control aim at the detection of prohibited substances (often registered drugs) in biological matrices and are hence related fields of analysis. In both fields, the detection of such a prohibited substance has legal and economical implications for the persons involved (farmer, horse-owner, trainer or athlete). Hence, the necessary precautions need to be taken to ensure that the unequivocal presence of a substance has indeed been established. In each of these fields of analysis, chromatography and mass spectrometry are the primary techniques used in the identification process and, not surprisingly, the criteria to which these techniques must comply depend on the regulatory authority. It seems illogical that different sets of criteria exist for fields of analysis that are so closely related. However, because of the complexity encountered in these analyses, the creation of an “ideal” set of criteria encompassing and foreseeing all possible difficulties met by the analyst during his work seems impossible. This paper tries to give an overview of the similarities and differences in each set of regulations, while critically pointing out and illustrating pitfalls and positive aspects of each set of regulations in an attempt to aid the analyst in the decision process when regulations leave room for interpretation. The need for the analyst to critically evaluate the regulations is illustrated in two examples.
Starting Page	S39
Ending Page	S44
File Format	PDF
ISSN	00095893
Journal	Chromatographia
Volume Number	59
Issue Number	1
e-ISSN	16121112
Language	English
Publisher	Vieweg Verlag
Publisher Date	2004-02-26
Publisher Place	Wiesbaden
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Column liquid chromatography Gas chromatography Mass spectrometry Residue analysis Doping control
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Analytical Chemistry Biochemistry Clinical Biochemistry

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