NDLI: Examination of Template Structural Effects on CEC Chiral Separation Performance of Molecule Imprinted Polymers Made by a Generalized Preparation Protocol

Content Provider	Springer Nature Link
Author	Zaidi, Shabi Abbas Lee, Seung Mi AL Othman, Zeid A. AL Majid, Abdullah M. Cheong, Won Jo
Copyright Year	2011
Abstract	Some acidic chiral templates were used to prepare open tubular (OT) molecule imprinted polymer (MIP) capillary columns to explore the effects of molecular structures of templates on chiral recognition capabilities and to verify the feasibility of the general MIP preparation protocol introduced in the previous study. The templates are phenyl carboxylic acids and their derivatives. Optimization was carried out for chiral separation of template enantiomers for each MIP column through varying pH and composition of eluent. It was found that the preparation protocol can be successfully applied for the appropriate templates with functional groups fulfilling the three-points interaction rule. The chiral separation performances were quite satisfactory for MIPs of such templates although they are yet inferior to the separation performances of the MIP columns fabricated with the templates of profen drugs (2-arylpropionic acids with a large substituent on the phenyl ring). Subtle variations of the template molecular structures have been found to be critical to enhance chiral recognition ability of the resultant MIP column.
Starting Page	517
Ending Page	525
Page Count	9
File Format	PDF
ISSN	00095893
Journal	Chromatographia
Volume Number	73
Issue Number	5-6
e-ISSN	16121112
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-02-08
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Capillary electrochromatography Molecule imprinted polymer Chiral separation Template structural effects Generalized preparation protocol Pharmacy Plant Sciences Organic Chemistry Analytical Chemistry Biochemistry Proteomics
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Analytical Chemistry Biochemistry Clinical Biochemistry

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