NDLI: Chemical Characterization of Phenolic Compounds in Erigeron Injection by Rapid-Resolution LC Coupled with Multi-Stage and Quadrupole-TOF-MS

Content Provider	Springer Nature Link
Author	Zhang, Yufeng Zhao, Qinqin Ma, Jinfei Wu, Bin Zeng, Xing
Copyright Year	2010
Abstract	Rapid-resolution liquid chromatography coupled with electrospray ion trap multistage mass spectrometry (ESI-MSn) and electrospray quadrupole-time-of-flight mass spectrometry (ESI-Q-TOF) has been utilized to separate and characterize the phenolic components in Erigeron injections. After extensive separation on the column, each peaks’ potential structures were obtained based on their accurate mass supplied by ESI-Q-TOF and chemical database retrieval, and confirmed by ESI-MSn. A total of 44 compounds were identified or tentatively characterized and fifteen of them reported for the first time. In addition, the developed method was applied to monitor the elimination of phenolic compounds in rats after intravenous administration of 4 mL kg−1 Erigeron injection. The caffeoylquinic acids and flavonoids of the Erigeron injection were quickly degraded and most of them reached the low limit of detection (SNR < 3) at 2 h post-injection.
Starting Page	651
Ending Page	658
Page Count	8
File Format	PDF
ISSN	00095893
Journal	Chromatographia
Volume Number	72
Issue Number	7-8
e-ISSN	16121112
Language	English
Publisher	Vieweg Verlag
Publisher Date	2010-08-14
Publisher Place	Wiesbaden
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Column liquid chromatography Rapid-resolution liquid chromatography ESI-MSn and ESI-Q-TOF Erigeron injection Phenolic compounds Measurement Science and Instrumentation Plant Sciences Biochemistry Pharmacy Organic Chemistry Analytical Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Analytical Chemistry Biochemistry Clinical Biochemistry

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