NDLI: Cholesterol-fed ovariectomized monkeys are good animal models for human atherosclerosis of postmenopausal women

Please wait, while we are loading the content...

Plasma insulin-like growth factor-I, testosterone and morphological changes in the growth of captive agile gibbons (Hylobates agilis) from birth to adolescence

Life-history parameters of a wild group of West African patas monkeys (Erythrocebus patas patas)

Familial early onset macular degeneration in cynomolgus monkeys (Macaca fascicularis)

Walter C. Hartwig (ed): The Primate Fossil Record : Cambridge University Press, Cambridge, 2002

M.M. Robbins, P. Sicotte, K.J. Stewart (eds) Mountain gorillas: three decades of research at Karisoke : Cambridge University Press, Cambridge

Daris R. Swindler: Primate dentition: an introduction to the teeth of non-human primates. Cambridge studies in biological and evolutionary anthropology 32 : Cambridge University Press, pp 1–296

Eman P. Fridman: Medical primatology – history, biological foundations and applications (edited by Ronald D. Nadler)

A. Fuentes, L.D. Wolfe: Primates face to face: the conservation implications of human-nonhuman primate interconnections. Cambridge studies in biological and evolutionary anthropology 29 : Cambridge University Press, Cambridge, 2002

Lynne E. Miller (ed): Eat or be eaten: predator sensitive foraging among primates : Cambridge University Press, Cambridge, 2002. 297 pp

Primates : Volume 44, Issue 2, April 2003

Primates : Volume 44, Issue 1, January 2003

Cholesterol-fed ovariectomized monkeys are good animal models for human atherosclerosis of postmenopausal women

Content Provider	Springer Nature Link
Author	Torii, Ryuzo Shiomi, Masashi Ito, Takashi Yamada, Satoshi Eguchi, Yutaka Ikeda, rimichi
Copyright Year	2003
Abstract	Although it is well known that the incidence of atherosclerosis is markedly increased in postmenopausal women, antiatherosclerotic effects of estrogen replacement therapies are not clear. One of the reasons for this is due to the lack of appropriate animal models for atherosclerosis of postmenopausal women. Therefore, we attempted to develop an animal model for atherosclerosis of postmenopausal women and examined the antiatherosclerotic effects of estrogen replacement therapy. Adult ovariectomized Japanese monkeys were fed 2% cholesterol diet alone (C-group) or in combination with conjugated estrogen (CE-group) for 30 months. The serum estradiol-17β levels of the CE-group were varied between 10 and 204.5 ng/dl during treatment. In the C-group, the serum total cholesterol levels were increased from 110 to 270 mg/dl, and atheroma was first observed after 3-months treatment with angioscopy. In the CE-group, the levels of the serum total cholesterol during treatment were 30% lower than those of the C-group, and the aortic lesions were first observed after 12-months treatment with angioscopy. The aortic intimal thickness of the CE-group was 58% of the C-group. This finding showed good agreement with the angioscopic observation. The aortic lesions were of a fibromuscular type in both groups. In conclusion, a cholesterol-fed ovariectomized monkey is an appropriate animal model for atherosclerosis of postmenopausal women. Furthermore, angiofiberscopic and histopathological observations suggested that estrogen replacement therapy was valid for atherosclerosis of postmenopausal women.
Starting Page	247
Ending Page	252
Page Count	6
File Format	PDF
ISSN	00328332
Journal	Primates
Volume Number	44
Issue Number	3
e-ISSN	16107365
Language	English
Publisher	Springer-Verlag
Publisher Date	2003-04-25
Publisher Place	Tokyo
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Angiofiberscopic observation Atherosclerosis Estrogen replacement therapy Ovariectomized monkey Postmenopausal disease
Content Type	Text
Resource Type	Article
Subject	Animal Science and Zoology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Hormone Replacement Therapy and Cardiovascular Disease: Lessons from a Monkey Model of Postmenopausal Women

Estrogen monotherapy and combined estrogen-progestogen replacement therapy attenuate aortic accumulation of cholesterol in ovariectomized cholesterol-fed rabbits.

Behavioral/systems/cognitive cyclic estrogen replacement improves cognitive function in aged ovariectomized rhesus monkeys.

Spider monkey, Muriqui and Woolly monkey relationships revisited

Raloxifene and estrogen reduces progression of advanced atherosclerosis--a study in ovariectomized, cholesterol-fed rabbits.

Randomized controlled trial evidence that estrogen replacement therapy reduces the progression of subclinical atherosclerosis in healthy postmenopausal women without preexisting cardiovascular disease.

Hormone Replacement Therapy and Cardiovascular Disease: Lessons from a Monkey Model of Postmenopausal Women

Estrogen replacement therapy on c-reactive protein in postmenopausal women. J am coll.

Postmenopausal hormone replacement therapy: implications for prolonging life.

Cholesterol-fed ovariectomized monkeys are good animal models for human atherosclerosis of postmenopausal women

Similar Documents

Hormone Replacement Therapy and Cardiovascular Disease: Lessons from a Monkey Model of Postmenopausal Women

Estrogen monotherapy and combined estrogen-progestogen replacement therapy attenuate aortic accumulation of cholesterol in ovariectomized cholesterol-fed rabbits.

Behavioral/systems/cognitive cyclic estrogen replacement improves cognitive function in aged ovariectomized rhesus monkeys.

Spider monkey, Muriqui and Woolly monkey relationships revisited

Raloxifene and estrogen reduces progression of advanced atherosclerosis--a study in ovariectomized, cholesterol-fed rabbits.

Randomized controlled trial evidence that estrogen replacement therapy reduces the progression of subclinical atherosclerosis in healthy postmenopausal women without preexisting cardiovascular disease.

Hormone Replacement Therapy and Cardiovascular Disease: Lessons from a Monkey Model of Postmenopausal Women

Estrogen replacement therapy on c-reactive protein in postmenopausal women. J am coll.

Postmenopausal hormone replacement therapy: implications for prolonging life.

Cholesterol-fed ovariectomized monkeys are good animal models for human atherosclerosis of postmenopausal women