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| Content Provider | Springer Nature Link |
|---|---|
| Author | Rusu, Aura Hancu, Gabriel Uivaroşi, Valentina |
| Copyright Year | 2014 |
| Abstract | Fluoroquinolones are a valuable synthetic antibacterial class widely used in the treatment of infectious diseases both in humans and animals. Until recently, it has been thought that bacterial resistance to fluoroquinolones develops very slowly. Nowadays, there are multiple studies that reveal the alarming occurrence of bacterial resistance and there is a high risk of becoming therapeutically useless. The emergence of this phenomenon comes from injudicious usage in therapy, the presence of residues and their metabolites in food of animal origin and also in sewage, compost and domestic waste, which end up in soil and water sources. In the present paper, we reviewed important issues regarding fluoroquinolones impact on the environment in connection with the development of bacterial resistance: (1) the presence of fluoroquinolones as pollutants in soil, surface waters, and food. Fluoroquinolones are persistent with high specificity to interact with soil compared to other antibiotics. Pollution of water sources raises concerns regarding the effects of small concentrations (ng L−1) on human health and also of the environment. The non-therapeutic use in animal farms conducts to food pollution; the cultivated plants could concentrate the fluoroquinolones (over 100 μg L−1); (2) the increase of bacterial resistance to fluoroquinolones occurring with specific mutations in the target enzymes as well by the plasmid-mediated resistance and active efflux of the cell; (3) international regulations of the fluoroquinolone residues in food that are far to encompass all compounds; (4) fluoroquinolones residues analysis with standardized methods should provide limits of detection lower than maximum residue limit values; and (5) trends and perspectives: (a) a wider process of harmonization of regulations; (b) the fluoroquinolones restriction, necessary for low levels of bacterial resistance; (c) the soil and waste water purification methods; (d) the practice of soil planting scheme as an alternative; and (e) an environmental label in order to facilitate the selection of drugs. |
| Starting Page | 21 |
| Ending Page | 36 |
| Page Count | 16 |
| File Format | |
| ISSN | 16103653 |
| Journal | Environmental Chemistry Letters |
| Volume Number | 13 |
| Issue Number | 1 |
| e-ISSN | 16103661 |
| Language | English |
| Publisher | Springer International Publishing |
| Publisher Date | 2014-09-08 |
| Publisher Place | Cham |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Fluoroquinolones Bacterial resistance Environmental pollution Antibiotic Occurrence Environmental Chemistry Ecotoxicology Pollution Analytical Chemistry Geochemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Environmental Chemistry |
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