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Flow-dependent concentration polarization and the endothelial glycocalyx layer: multi-scale aspects of arterial mass transport and their implications for atherosclerosis

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Biomechanics and Modeling in Mechanobiology : Volume 13, Issue 1, January 2014

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Flow-dependent concentration polarization and the endothelial glycocalyx layer: multi-scale aspects of arterial mass transport and their implications for atherosclerosis

Content Provider	Springer Nature Link
Author	Vincent, P. E. Weinberg, P. D.
Copyright Year	2013
Abstract	Atherosclerosis is the underlying cause of most heart attacks and strokes. It is thereby the leading cause of death in the Western world, and it places a significant financial burden on health care systems. There is evidence that complex, multi-scale arterial mass transport processes play a key role in the development of atherosclerosis. Such processes can be controlled both by blood flow patterns and by properties of the arterial wall. This short review focuses on one vascular-scale, flow-regulated arterial mass transport process, namely concentration polarization of low density lipoprotein at the luminal surface of the arterial endothelium, and on one cellular-scale, structural determinant of arterial wall mass transport, namely the endothelial glycocalyx layer. Both have attracted significant attention in recent years. In addition to reviewing and appraising relevant literature, we propose various directions for future work.
Starting Page	313
Ending Page	326
Page Count	14
File Format	PDF
ISSN	16177959
Journal	Biomechanics and Modeling in Mechanobiology
Volume Number	13
Issue Number	2
e-ISSN	16177940
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2013-07-09
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Atherosclerosis Mass transport Endothelial glycocalyx layer Concentration polarization Low density lipoprotein Theoretical and Applied Mechanics Biomedical Engineering Biophysics and Biological Physics
Content Type	Text
Resource Type	Article
Subject	Mechanical Engineering Modeling and Simulation Biotechnology

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