NDLI: Multi-scale mechanics of traumatic brain injury: predicting axonal strains from head loads

Please wait, while we are loading the content...

Stress relaxation of swine growth plate in semi-confined compression: depth dependent tissue deformational behavior versus extracellular matrix composition and collagen fiber organization

Computational simulations of hemodynamic changes within thoracic, coronary, and cerebral arteries following early wall remodeling in response to distal aortic coarctation

Microdomain heterogeneity in 3D affects the mechanics of neonatal cardiac myocyte contraction

Effect of the glycocalyx layer on transmission of interstitial flow shear stress to embedded cells

A three-constituent damage model for arterial clamping in computer-assisted surgery

Multi-scale mechanics of traumatic brain injury: predicting axonal strains from head loads

Analytical and numerical analyses of the micromechanics of soft fibrous connective tissues

Computational model for the cell-mechanical response of the osteocyte cytoskeleton based on self-stabilizing tensegrity structures

Investigation of the influence of reflection on the attenuation of cancellous bone

Biomechanics and Modeling in Mechanobiology : Volume 11

Biomechanics and Modeling in Mechanobiology : Volume 10

Biomechanics and Modeling in Mechanobiology : Volume 9

Biomechanics and Modeling in Mechanobiology : Volume 8

Biomechanics and Modeling in Mechanobiology : Volume 7

Biomechanics and Modeling in Mechanobiology : Volume 6

Biomechanics and Modeling in Mechanobiology : Volume 5

Biomechanics and Modeling in Mechanobiology : Volume 4

Biomechanics and Modeling in Mechanobiology : Volume 3

Biomechanics and Modeling in Mechanobiology : Volume 2

Biomechanics and Modeling in Mechanobiology : Volume 1

Multi-scale mechanics of traumatic brain injury: predicting axonal strains from head loads

Content Provider	Springer Nature Link
Author	Cloots, R. J. H. Dommelen, J. A. W. Kleiven, S. Geers, M. G. D.
Copyright Year	2012
Abstract	The length scales involved in the development of diffuse axonal injury typically range from the head level (i.e., mechanical loading) to the cellular level. The parts of the brain that are vulnerable to this type of injury are mainly the brainstem and the corpus callosum, which are regions with highly anisotropically oriented axons. Within these parts, discrete axonal injuries occur mainly where the axons have to deviate from their main course due to the presence of an inclusion. The aim of this study is to predict axonal strains as a result of a mechanical load at the macroscopic head level. For this, a multi-scale finite element approach is adopted, in which a macro-level head model and a micro-level critical volume element are coupled. The results show that the axonal strains cannot be trivially correlated to the tissue strain without taking into account the axonal orientations, which indicates that the heterogeneities at the cellular level play an important role in brain injury and reliable predictions thereof. In addition to the multi-scale approach, it is shown that a novel anisotropic equivalent strain measure can be used to assess these micro-scale effects from head-level simulations only.
Starting Page	137
Ending Page	150
Page Count	14
File Format	PDF
ISSN	16177959
Journal	Biomechanics and Modeling in Mechanobiology
Volume Number	12
Issue Number	1
e-ISSN	16177940
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-03-21
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Traumatic brain injury TBI Diffuse axonal injury DAI Injury criteria Head model Finite element method Multi-scale Theoretical and Applied Mechanics Biomedical Engineering Biophysics and Biological Physics
Content Type	Text
Resource Type	Article
Subject	Mechanical Engineering Modeling and Simulation Biotechnology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Multi-scale mechanics of traumatic brain injury: predicting axonal strains from head loads

An axonal strain injury criterion for traumatic brain injury

Micromechanics of diffuse axonal injury: influence of axonal orientation and anisotropy

Micromechanics of diffuse axonal injury: influence of axonal orientation and anisotropy

White matter tract-oriented deformation predicts traumatic axonal brain injury and reveals rotational direction-specific vulnerabilities

Investigate the Variations of the Head and Brain Response in a Rodent Head Impact Acceleration Model by Finite Element Modeling

Injury Biomechanics of a Child's Head: Problems, Challenges and Possibilities with a new aHEAD Finite Element Model

Assessment of Kinematic Brain Injury Metrics for Predicting Strain Responses in Diverse Automotive Impact Conditions

Numerical Investigation of Axonal Damage for Regular and Irregular Axonal Distributions

Multi-scale mechanics of traumatic brain injury: predicting axonal strains from head loads

Similar Documents

Multi-scale mechanics of traumatic brain injury: predicting axonal strains from head loads

An axonal strain injury criterion for traumatic brain injury

Micromechanics of diffuse axonal injury: influence of axonal orientation and anisotropy

Micromechanics of diffuse axonal injury: influence of axonal orientation and anisotropy

White matter tract-oriented deformation predicts traumatic axonal brain injury and reveals rotational direction-specific vulnerabilities

Investigate the Variations of the Head and Brain Response in a Rodent Head Impact Acceleration Model by Finite Element Modeling

Injury Biomechanics of a Child's Head: Problems, Challenges and Possibilities with a new aHEAD Finite Element Model

Assessment of Kinematic Brain Injury Metrics for Predicting Strain Responses in Diverse Automotive Impact Conditions

Numerical Investigation of Axonal Damage for Regular and Irregular Axonal Distributions

Multi-scale mechanics of traumatic brain injury: predicting axonal strains from head loads