NDLI: Bone ingrowth around porous-coated acetabular implant: a three-dimensional finite element study using mechanoregulatory algorithm

Content Provider	Springer Nature Link
Author	Mukherjee, Kaushik Gupta, Sanjay
Copyright Year	2015
Abstract	Fixation of uncemented implant is influenced by peri-prosthetic bone ingrowth, which is dependent on the mechanical environment of the implant–bone structure. The objective of the study is to gain an insight into the tissue differentiation around an acetabular component. A mapping framework has been developed to simulate appropriate mechanical environment in the three-dimensional microscale model, implement the mechanoregulatory tissue differentiation algorithm and subsequently assess spatial distribution of bone ingrowth around an acetabular component, quantitatively. The FE model of implanted pelvis subjected to eight static load cases during a normal walking cycle was first solved. Thereafter, a mapping algorithm has been employed to include the variations in implant–bone relative displacement and host bone material properties from the macroscale FE model of implanted pelvis to the microscale FE model of the beaded implant–bone interface. The evolutionary tissue differentiation was observed in each of the 13 microscale models corresponding to 13 acetabular regions. The total implant–bone relative displacements, averaged over each region of the acetabulum, were found to vary between 10 and 60 $$μ \hbox {m}$$ . Both the linear elastic and biphasic poroelastic models predicted similar mechanoregulatory peri-prosthetic tissue differentiation. Considerable variations in bone ingrowth (13–88 %), interdigitation depth (0.2–0.82 mm) and average tissue Young’s modulus (970–3430 MPa) were predicted around the acetabular cup. A progressive increase in the average Young’s modulus, interdigitation depth and decrease in average radial strains of newly formed tissue layer were also observed. This scheme can be extended to investigate tissue differentiation for different surface texture designs on the implants.
Starting Page	389
Ending Page	403
Page Count	15
File Format	PDF
ISSN	16177959
Journal	Biomechanics and Modeling in Mechanobiology
Volume Number	15
Issue Number	2
e-ISSN	16177940
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2015-07-01
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Tissue differentiation Mechanoregulatory algorithm Uncemented acetabular implant Linear elastic model Biphasic poroelastic model Theoretical and Applied Mechanics Biomedical Engineering Biophysics and Biological Physics
Content Type	Text
Resource Type	Article
Subject	Mechanical Engineering Modeling and Simulation Biotechnology

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