NDLI: Physiologically based mathematical model of transduction of mechanobiological signals by osteocytes

Content Provider	Springer Nature Link
Author	Hambli, Ridha Rieger, Romain
Copyright Year	2011
Abstract	Developing mathematical models describing the bone transduction mechanisms, including mechanical and metabolic regulations, has a clear practical applications in bone tissue engineering. The current study attempts to develop a plausible physiologically based mathematical model to describe the mechanotransduction in bone by an osteocyte mediated by the calcium-parathyroid hormone regulation and incorporating the nitric oxide (NO) and prostaglandin E2 (PGE2) effects in early responses to mechanical stimulation. The inputs are mechanical stress and calcium concentration, and the output is a stimulus function corresponding to the stimulatory signal to osteoblasts. The focus will be on the development of the mechanotransduction model rather than investigating the bone remodeling process that is beyond the scope of this study. The different components of the model were based on both experimental and theoretical previously published results describing some observed physiological events in bone mechanotransduction. Current model is a dynamical system expressing the mechanotransduction response of a given osteocyte with zero explicit space dimensions, but with a dependent variable that records signal amplitude as a function of mechanical stress, some metabolic factors release, and time. We then investigated the model response in term of stimulus signal variation versus the model inputs. Despite the limitations of the model, predicted and experimental results from literature have the same trends.
Starting Page	83
Ending Page	93
Page Count	11
File Format	PDF
ISSN	16177959
Journal	Biomechanics and Modeling in Mechanobiology
Volume Number	11
Issue Number	1-2
e-ISSN	16177940
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-02-20
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Bone mechanotransduction Osteocytes Shear stress Ca-PTH NO-PGE2 interactions Mechanobiology Biomedical Engineering Theoretical and Applied Mechanics Biophysics and Biological Physics
Content Type	Text
Resource Type	Article
Subject	Mechanical Engineering Modeling and Simulation Biotechnology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The mechanobiological effects of periosteal surface loads

Mechanotransduction of bone cellsin vitro: Mechanobiology of bone tissue

Toward Mechanical Systems Biology in Bone

Fluid flow in the osteocyte mechanical environment: a fluid–structure interaction approach

A mechanobiological model of orthodontic tooth movement

Dynamic modeling for shear stress induced ATP release from vascular endothelial cells

The spatio-temporal arrangement of different tissues during bone healing as a result of simple mechanobiological rules

Simulation of intracellular $$\hbox {Ca}^{2+}$$ transients in osteoblasts induced by fluid shear stress and its application

A Trabecular Bone Explant Model of Osteocyte–Osteoblast Co-Culture for Bone Mechanobiology

Physiologically based mathematical model of transduction of mechanobiological signals by osteocytes

Similar Documents

The mechanobiological effects of periosteal surface loads

Mechanotransduction of bone cellsin vitro: Mechanobiology of bone tissue

Toward Mechanical Systems Biology in Bone

Fluid flow in the osteocyte mechanical environment: a fluid–structure interaction approach

A mechanobiological model of orthodontic tooth movement

Dynamic modeling for shear stress induced ATP release from vascular endothelial cells

The spatio-temporal arrangement of different tissues during bone healing as a result of simple mechanobiological rules

Simulation of intracellular $$\hbox {Ca}^{2+}$$ transients in osteoblasts induced by fluid shear stress and its application

A Trabecular Bone Explant Model of Osteocyte–Osteoblast Co-Culture for Bone Mechanobiology

Physiologically based mathematical model of transduction of mechanobiological signals by osteocytes