NDLI: Effect of Epstein–Barr virus infection on global gene expression in nasopharyngeal carcinoma

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Effect of Epstein–Barr virus infection on global gene expression in nasopharyngeal carcinoma

Functional & Integrative Genomics : Volume 6

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Effect of Epstein–Barr virus infection on global gene expression in nasopharyngeal carcinoma

Content Provider	Springer Nature Link
Author	Lee, Yuan Chii Gladys Hwang, Yu Chyi Chen, Kuang Chi Lin, Yong Shiang Huang, Dah Yeou Huang, Tao Wei Kao, Cheng Yan Wu, Han Chung Lin, Chin Tarng Huang, Chi Ying F.
Copyright Year	2006
Abstract	It was proposed that Epstein–Barr virus (EBV) is closely associated with nasopharyngeal carcinoma (NPC); however, the molecular mechanisms involved in the effect of EBV on NPC host genes have not yet been well defined. For this study, two sets of microarray experiments, NPC (EBV-free) vs normal epithelial cells and EBV+ vs EBV− NPC arrays, were analyzed and the datasets were cross-compared to identify any correlation between gene clusters involved in EBV targeting and the NPC host gene expression profiles. Statistical analysis revealed that EBV seems to have a preference for targeting more genes from the differentially expressed group in NPC cells than those from the ubiquitously expressed group. Furthermore, this trend is also reflected in log ratios where the EBV target genes of the differentially expressed group origin showed greater log ratios than genes with an origin from the ubiquitously expressed NPC group. Taken together, the genome-wide comparative scanning of EBV and NPC transcriptomes has successfully demonstrated that EBV infection has an intensifying effect on the signals involved in NPC gene expression both in breadth (the majority of the genes) and in depth (greater log ratios).
Starting Page	79
Ending Page	93
Page Count	15
File Format	PDF
ISSN	1438793X
Journal	Functional & Integrative Genomics
Volume Number	7
Issue Number	1
e-ISSN	14387948
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-09-19
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Epstein–Barr virus (EBV) Nasopharyngeal carcinoma (NPC) Transcriptomes Quantitative real-time reverse transcriptase polymerase chain reaction (Q-RT-PCR) Animal Genetics and Genomics Bioinformatics Biochemistry Microbial Genetics and Genomics Plant Genetics & Genomics Cell Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine

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