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| Content Provider | Springer Nature Link |
|---|---|
| Author | Li, Cong jun Li, Robert W Wang, Yong hong Elsasser, Ted H. |
| Copyright Year | 2006 |
| Abstract | Ruminant species have evolved to metabolize the short-chain volatile fatty acids (VFA), acetate, propionate, and butyrate, to fulfill up to 70% of their nutrient energy requirements. The inherent VFA dependence of ruminant cells was exploited to add a level of increased sensitivity to the study of the role of butyrate gene-response elements in regulatory biochemical pathways. Global gene expression profiles of the bovine kidney epithelial cells regulated by sodium butyrate were investigated with high-density oligonucleotide microarrays. The detailed mechanisms by which butyrate induces cell growth arrest and apoptosis were analyzed using the Ingenuity Pathways Knowledge Base. The functional category and pathway analyses of the microarray data revealed that four canonical pathways (Cell cycles: G2/M DNA damage checkpoint, and pyrimidine metabolism; G1/S checkpoint regulation and purine metabolism) were significantly perturbed. The biologically relevant networks and pathways of these genes were also identified. IGF2, TGFB1, TP53, E2F4, and CDC2 were established as being centered in these genomic networks. The present findings provide a basis for understanding the full range of the biological roles and the molecular mechanisms that butyrate may play in animal cell growth, proliferation, and energy metabolisms. |
| Starting Page | 193 |
| Ending Page | 205 |
| Page Count | 13 |
| File Format | |
| ISSN | 1438793X |
| Journal | Functional & Integrative Genomics |
| Volume Number | 7 |
| Issue Number | 3 |
| e-ISSN | 14387948 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2006-12-21 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Apoptosis Butyrate Cell cycle Genetic network Animal Genetics and Genomics Bioinformatics Biochemistry Microbial Genetics and Genomics Plant Genetics & Genomics Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Medicine |
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