NDLI: Identification and expression of liver-specific genes after LPS challenge in amphioxus: the hepatic cecum as liver-like organ and “pre-hepatic” acute phase response

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Identification and expression of liver-specific genes after LPS challenge in amphioxus: the hepatic cecum as liver-like organ and “pre-hepatic” acute phase response

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Functional & Integrative Genomics : Volume 10

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Identification and expression of liver-specific genes after LPS challenge in amphioxus: the hepatic cecum as liver-like organ and “pre-hepatic” acute phase response

Content Provider	Springer Nature Link
Author	Wang, Yuan Zhang, Shicui
Copyright Year	2010
Abstract	Liver is present in all vertebrates and central to many physiological processes including processing of nutrients from ingested food, plasma protein synthesis, hormone production, and detoxification. However, its evolutionary origin remains open to date. Liver is also the principal organ of acute phase response (APR) but when the vertebrate-like APR regulatory network emerges during the chordate evolution is unknown. By combining global genome survey and qRT-PCR data sets, here, we clearly demonstrate the presence of the 58 vertebrate (zebrafish) liver-specific genes in amphioxus (hepatic cecum-specific genes) that are expressed in a tissue-specific manner in the hepatic cecum, the homolog of liver. Among these 58 hepatic cecum-specific genes, 52 genes respond to lipopolysaccharide challenge, which show similar expression profiles in both zebrafish and amphioxus. In addition, searching for binding sites for HNF and APR-associated transcription factors in promoter sequences for all the 58 hepatic cecum-specific genes and the 52 APR-related genes suggests that both HNF factors and APR-associated transcription factors in amphioxus form regulatory networks similar to those observed in zebrafish, regulating the hepatic cecum-specific genes and APR-related genes, respectively, via binding to their binding sites in the promoter regions. These similarities in liver/hepatic cecum-specific genes, APR, and regulatory networks between amphioxus and zebrafish supports the idea that hepatic cecum in amphioxus is the “pre-hepatic” organ homologous to vertebrate liver and acts as an immunological organ, playing an important role in APR.
Starting Page	111
Ending Page	118
Page Count	8
File Format	PDF
ISSN	1438793X
Journal	Functional & Integrative Genomics
Volume Number	11
Issue Number	1
e-ISSN	14387948
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-11-04
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Amphioxus Hepatic cecum Liver-specific genes Acute phase response Transcription factors Promoter analysis Biochemistry Bioinformatics Plant Genetics & Genomics Animal Genetics and Genomics Microbial Genetics and Genomics Cell Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine

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Identification and expression of liver-specific genes after LPS challenge in amphioxus: the hepatic cecum as liver-like organ and “pre-hepatic” acute phase response

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