NDLI: Dynamic architecture of the yeast cell cycle uncovered by wavelet decomposition of expression microarray data

Content Provider	Springer Nature Link
Author	Klevecz, Robert R.
Copyright Year	2000
Abstract	Wavelet analysis has been applied to yeast cell cycle expression microchip data to reveal large-scale temporal structures and ubiquitous oscillations in mRNA levels. Discrete intervals in time within the cell cycle when expression levels changed were visualized as contour maps in which points of transition in gene expression among all 6178 genes were plotted as a function of cell cycle time. Time-frequency analysis using wavelet transforms supported the direct visualization and led to the conclusion that the predominant period is not the cell cycle but a higher frequency, 40 min, submultiple of the cycle. Each of the 6178 gene expression profiles was dissected by wavelet decomposition into all permitted frequencies from the Nyquist limit to roughly twice the cell cycle length. Transitions associated with maximum up- or down-regulation of mRNA levels appear as bands at circa 40-min intervals, half the length of the cycle, through two cell cycles. More than two thirds of the genes, including many of the cyclins, showed this half-cycle periodicity. Gene expression and events within the yeast cell cycle may be regulated by an attractor whose fundamental period is an emergent property of dynamic interactions within the yeast transcriptome.
Starting Page	186
Ending Page	192
Page Count	7
File Format	PDF
ISSN	1438793X
Journal	Functional & Integrative Genomics
Volume Number	1
Issue Number	3
Language	English
Publisher	Springer-Verlag
Publisher Date	2014-02-01
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cell Biology Plant Genetics & Genomics Microbial Genetics and Genomics Biochemistry Bioinformatics Animal Genetics and Genomics
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine

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