NDLI: Production of Manoalide and Its Analogues by the Sponge Luffariella variabilis Is Hardwired

Content Provider	Springer Nature Link
Author	Ettinger Epstein, Piers Tapiolas, Dianne M. Motti, Cherie A. Wright, Anthony D. Battershill, Christopher N. Nys, Rocky
Copyright Year	2007
Abstract	The Great Barrier Reef sponge Luffariella variabilis (Poléjaeff 1884) produces a range of potent anti-inflammatory compounds as its major metabolites. These major metabolites—manoalide monoacetate, manoalide, luffariellin A and seco-manoalide—were monitored temporally and spatially to quantify the potential yield from wild harvest or aquaculture. Production of the major metabolites was hardwired at the population level with little variation in space and time over meters to tens of kilometers in the Palm Islands, Queensland, Australia. Manoalide monoacetate (35 to 70 mg g−1 dry weight of sponge) was consistently the most abundant compound followed by manoalide (15 to 20 mg g−1 dry weight). Luffariellin A and seco-manoalide were 10 to 70 times less abundant and varied between 0 and 3 mg g−1 dry weight. On a larger spatial scale, L. variabilis from Davies Reef and Magnetic Island contained the same rank order and yields of compounds as the Palm Islands, indicating a generality of pattern over at least 100 km. The “hardwiring” of metabolite production at the population level by L. variabilis was also reflected in the lack of any inductive effect on metabolite production. In addition, individually monitored sponges produced fixed ratios of the major metabolites over time (years). However, these ratios varied between individuals, with some individuals consistently producing high levels of manoalide and manoalide monoacetate, providing the potential for selection of high-yielding stocks.
Starting Page	64
Ending Page	74
Page Count	11
File Format	PDF
ISSN	14362228
Journal	Marine Biotechnology
Volume Number	10
Issue Number	1
e-ISSN	14362236
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-09-25
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	chemical ecology constitutive and activated defense sponge manoalide production variation Engineering Zoology Microbiology Freshwater & Marine Ecology
Content Type	Text
Resource Type	Article
Subject	Aquatic Science Biotechnology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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