NDLI: Ureaplasma parvum causes hyperammonemia in a pharmacologically immunocompromised murine model

Content Provider	Springer Nature Link
Author	Wang, X. Greenwood Quaintance, K. E. Karau, M. J. Block, D. R. Mandrekar, J. N. Cunningham, S. A. Mallea, J. M. Patel, R.
Copyright Year	2016
Abstract	A relationship between hyperammonemia and Ureaplasma infection has been shown in lung transplant recipients. We have demonstrated that Ureaplasma urealyticum causes hyperammonemia in a novel immunocompromised murine model. Herein, we determined whether Ureaplasma parvum can do the same. Male C3H mice were given mycophenolate mofetil, tacrolimus, and prednisone for 7 days, and then challenged with U. parvum intratracheally (IT) and/or intraperitoneally (IP), while continuing immunosuppression over 6 days. Plasma ammonia concentrations were determined and compared using Wilcoxon rank-sum tests. Plasma ammonia concentrations of immunosuppressed mice challenged IT/IP with spent broth (median, 188 μmol/L; range, 102–340 μmol/L) were similar to those of normal (median, 226 μmol/L; range, 154–284 μmol/L, p > 0.05), uninfected immunosuppressed (median, 231 μmol/L; range, 122–340 μmol/L, p > 0.05), and U. parvum IT/IP challenged immunocompetent (median, 226 μmol/L; range, 130–330 μmol/L, p > 0.05) mice. Immunosuppressed mice challenged with U. parvum IT/IP (median 343 μmol/L; range 136–1,000 μmol/L) or IP (median 307 μmol/L; range 132–692 μmol/L) had higher plasma ammonia concentrations than those challenged IT/IP with spent broth (p < 0.001). U. parvum can cause hyperammonemia in pharmacologically immunocompromised mice.
Starting Page	517
Ending Page	522
Page Count	6
File Format	PDF
ISSN	09349723
Journal	European Journal of Clinical Microbiology & Infectious Diseases
Volume Number	36
Issue Number	3
e-ISSN	14354373
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-10-28
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Medical Microbiology Internal Medicine
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Microbiology (medical)

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