NDLI: The slippery difficulty of ever containing drug resistance with current practices

Content Provider	Springer Nature Link
Author	Fullybright, R.
Copyright Year	2016
Abstract	It has previously been shown that the rate of drug resistance emergence in medicine is exponential, while we have been producing drugs at a much lower rate. Our ability to successfully contain resistance at any one time is function of how many drugs we have at our disposal to counter new resistances from pathogens. Here, we assess our level of preparedness through a mathematical comparison of the drug manufacture rate by the pharmaceutical industry with the resistance emergence rate in pathogens. To that effect, changes in the rates of growth of the drugs production and resistance emergence processes are computed over multiple time segments and compared. It is found that new resistance emergence rate in infectious diseases medicine remains mathematically and permanently ahead of the drugs production rate by the pharmaceutical industry. Consequently, we are not in a position to ever contain current or future strengths of resistance from pathogens. A review of current practices is called for.
Starting Page	603
Ending Page	609
Page Count	7
File Format	PDF
ISSN	09349723
Journal	European Journal of Clinical Microbiology & Infectious Diseases
Volume Number	36
Issue Number	4
e-ISSN	14354373
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-11-28
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Antibiotic Drug Resistance Rate Pathogen Pharmaceutical Infectious Disease Medical Microbiology Internal Medicine
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Microbiology (medical)

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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