NDLI: Protective effect of cinnamaldehyde on streptozotocin-induced damage in rat pancreatic β-cells

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Food Science and Biotechnology : Volume 19

Protective effect of cinnamaldehyde on streptozotocin-induced damage in rat pancreatic β-cells

Content Provider	Springer Nature Link
Author	Yuan, Hai Dan Huang, Bo Chung, Sung Hyun
Copyright Year	2011
Abstract	Cinnamaldehyde (CNA) is a primary constituent found in cinnamon (Cortex cinnamomi). Although antidiabetic and anti-inflammatory activities of cinnamon extract have been investigated in recent years, whether CNA is responsible for these activities is yet to be explored. In the present study, we investigated the protective effect of CNA on streptozotocin (STZ)-induced β-cell dysfunction in RINm5F rat insulinoma cells. CNA markedly inhibited nitric oxide (NO) and prostaglandin E2 (PGE2) productions in concentration-dependent manners. Parallel with these observations, the protein and mRNA levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 enzymes were inhibited by CNA in concentration-dependent manners. CNA also inhibited STZ-induced nuclear factor (NF)-κB activation via the prevention of inhibitory κBα (IκBα) phosphorylation and degradation. Moreover, CNA significantly suppressed STZ-induced phosphorylations of extracellular signalregulated kinase (ERK), c-Jun NH2-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) in concentration-dependent manners. These results suggest that CNA is an active constituent of the cinnamon, and CNA protects against STZ-induced pancreatic β-cell damage by down-regulations of iNOS and COX-2 gene expression through blocking of NF-κB and MAPKs activities.
Starting Page	1271
Ending Page	1276
Page Count	6
File Format	PDF
ISSN	12267708
Journal	Food Science and Biotechnology
Volume Number	20
Issue Number	5
e-ISSN	20926456
Language	English
Publisher	The Korean Society of Food Science and Technology
Publisher Date	2011-10-31
Publisher Place	Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	cinnamaldehyde (CNA) streptozotocin (STZ) nuclear factor (NF)-κB RINm5F cell Nutrition Food Science
Content Type	Text
Resource Type	Article
Subject	Applied Microbiology and Biotechnology Food Science Biotechnology

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