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| Content Provider | Springer Nature Link |
|---|---|
| Author | Cho, Jae Young Choi, Eun Hye Kang, Jung Il Choi, Changsun Chun, Hyang Sook |
| Copyright Year | 2013 |
| Abstract | The objective of this study was to investigate the possible protective effects of maca (Lepidium meyenii) extract (MLE) by supercritical fluid extraction on dextran sodium sulfate (DSS)-induced colitis. Experimental colitis was induced by giving male BALB/c mice 3% DSS in drinking water, and MLE (30 mg/kg BW), sulfasalazine (100 mg/kg BW) or vehicle were administered orally. DSS challenge caused significant body weight loss, rectal bleeding, diarrhea, shortened colon length, histological changes, and increased myeloperoxidase (MPO) activity in DSS-treated mice. Oral administration of MLE significantly relieved the symptoms of diarrhea and rectal bleeding, and reduced colonic MPO activity (p<0.05). MLE treatment inhibited expression of several colonic proteins related to inflammatory responses, such as interleukin (IL)-1β, tumor necrosis factor-α, IL-6, and S100 calcium-binding protein A8, whose expressions were increased significantly by DSS treatment. These results suggest that MLE can alleviate DSS-induced colitis in mice by modulating colonic inflammatory mediators. |
| Starting Page | 859 |
| Ending Page | 864 |
| Page Count | 6 |
| File Format | |
| ISSN | 12267708 |
| Journal | Food Science and Biotechnology |
| Volume Number | 22 |
| Issue Number | 3 |
| e-ISSN | 20926456 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2013-06-30 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | colitis dextran sulfate sodium inflammation maca extract supercritical fluid extraction Food Science Nutrition |
| Content Type | Text |
| Resource Type | Article |
| Subject | Applied Microbiology and Biotechnology Food Science Biotechnology |
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