NDLI: Ginsenoside 20(R)-Rg3 stimulates glucose uptake in C2C12 myotubes via CaMKK-AMPK pathways

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Ginsenoside 20(R)-Rg3 stimulates glucose uptake in C2C12 myotubes via CaMKK-AMPK pathways

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Food Science and Biotechnology : Volume 19, Issue 4, August 2010

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Food Science and Biotechnology : Volume 19, Issue 2, April 2010

Food Science and Biotechnology : Volume 19, Issue 1, February 2010

Ginsenoside 20(R)-Rg3 stimulates glucose uptake in C2C12 myotubes via CaMKK-AMPK pathways

Content Provider	Springer Nature Link
Author	Kim, Do Yeon Yuan, Hai Dan Huang, Bo Quan, Hai Yan Chung, Sung Hyun
Copyright Year	2010
Abstract	Based upon preliminary study showing stimulation of glucose uptake by 20(R)-Rg3, a stereoisomer of 20(S)-Rg3 ginsenoside found in red ginseng, we investigated the action mechanism of 20(R)-Rg3 in differentiated C2C12 myotubes. It was found that 20(R)-Rg3 stimulated translocation of glucose transporter 4 (GLUT4) and glucose uptake in a concentration-dependent manner. In addition, 20(R)-Rg3 phosphorylated AMP-activated protein kinase (AMPK) and Ca2+/Calmodulin-dependent protein kinase kinase (CaMKK) in time- and concentration-dependent manners. In the meantime, 20(R)-Rg3-induced glucose uptake and translocation of GLUT4 were attenuated in the presence of compound C (an AMPK inhibitor) or STO-609 (a CaMKK inhibitor). Taken together, this study is the first to demonstrate that 20(R)-Rg3 stimulated the glucose uptake via translocation of GLUT4 and this effect was seemed to be mediated by CaMKK-AMPK pathways in C2C12 myotubes.
Starting Page	1277
Ending Page	1282
Page Count	6
File Format	PDF
ISSN	12267708
Journal	Food Science and Biotechnology
Volume Number	19
Issue Number	5
e-ISSN	20926456
Language	English
Publisher	The Korean Society of Food Science and Technology
Publisher Date	2010-10-31
Publisher Place	Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	20(R)-ginsenoside Rg3 glucose uptake C2C12 myotube AMP-activated protein kinase Ca2+/Calmodulindependent protein kinase kinase Nutrition Food Science
Content Type	Text
Resource Type	Article
Subject	Applied Microbiology and Biotechnology Food Science Biotechnology

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