NDLI: Utilization of whey powder as an alternate carbon source for production of hypocholesterolemic drug by Aspergillus terreus MTCC 1281

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Utilization of whey powder as an alternate carbon source for production of hypocholesterolemic drug by Aspergillus terreus MTCC 1281

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Utilization of whey powder as an alternate carbon source for production of hypocholesterolemic drug by Aspergillus terreus MTCC 1281

Content Provider	Springer Nature Link
Author	Karthika, Chinnasamy Sharmila, Govindasamy Muthukumaran, Chandrasekaran Manikandan, Krishnan
Copyright Year	2013
Abstract	In this present study, we investigated the utilization of whey powder as an alternate carbon source and statistical optimization of medium components on lovastatin production by Aspergillus terreus MTCC 1281. Central composite design (CCD) of response surface methodology (RSM) was successfully employed to optimize the four medium variables whey powder, yeast extract, sodium chloride, and copper sulphate at five levels. Regression analysis explained that the linear and square effects of the variables were found significant with R 2 value of 0.937. Maximum lovastatin production of 358.2 mg/L was obtained with the predicted optimal concentration of whey powder 1.5%, yeast extract 0.75%, sodium chloride 0.04%, and copper sulphate 0.019%.The results of this study indicated that statistical optimization approach leads to high lovastatin production by using whey powder as a carbon source.
Starting Page	1
Ending Page	7
Page Count	7
File Format	PDF
ISSN	12267708
Journal	Food Science and Biotechnology
Volume Number	22
Issue Number	5
e-ISSN	20926456
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-09-07
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	whey powder lovastatin Aspergillus terreus response surface methodology (RSM) Food Science Nutrition
Content Type	Text
Resource Type	Article
Subject	Applied Microbiology and Biotechnology Food Science Biotechnology

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