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| Content Provider | Springer Nature Link |
|---|---|
| Author | Lee, Mee Sook Lee, Yun Kyoung Park, Ock Jin |
| Copyright Year | 2010 |
| Abstract | In this study, the potential of cherry silver berry (Elaeagnus multiflora) as a cancer preventive agent through regulating inflammatory signals including cyclooxygenase-2 (COX-2) and Akt was examined. Cherry silver berry has reported to exert anti-oxidative, anti-inflammatory, and anti-proliferative effects. The extracts from seed and flesh of cherry silver berry were obtained, and analyzed COX-2 and Akt activities in cherry silver berry extract treated HT-29 colon cancer cells. The results showed that the treatment of seed extracts reduced cell viability at the concentrations above 1,600 mg/mL, effectively reduced COX-2 and p-Akt expression. In addition, the anti-inflammatory effects seemed to be related to cancer cell death. Both of seed and flesh extracts inhibited cell growth and induced apoptosis in HT-29 cells. These results suggest that extracts of cherry silver berry may contribute to suppressing cancer growth through its anti-inflammatory and anti-proliferative effects, and natural products used as oriental medicine have the possibility to control tumor cell growth. |
| Starting Page | 1673 |
| Ending Page | 1677 |
| Page Count | 5 |
| File Format | |
| ISSN | 12267708 |
| Journal | Food Science and Biotechnology |
| Volume Number | 19 |
| Issue Number | 6 |
| e-ISSN | 20926456 |
| Language | English |
| Publisher | The Korean Society of Food Science and Technology |
| Publisher Date | 2010-12-31 |
| Publisher Place | Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Akt cyclooxygenase-2 apoptosis colon cancer Elaeagnus multiflora Nutrition Food Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Applied Microbiology and Biotechnology Food Science Biotechnology |
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