NDLI: No genetic association between the LRP receptor and sporadic or late-onset familial Alzheimer disease

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Recent progress in the genetics of human epilepsies

Clinical and molecular genetics of primary dystonias

No genetic association between the LRP receptor and sporadic or late-onset familial Alzheimer disease

Identification of two mutations and a polymorphism in the chloride channel CLCN-1 in patients with Becker's generalized myotonia

Genetic fine mapping of the Miyoshi myopathy locus and exclusion of eight candidate genes

Novel mutations of mitochondrial complex I in pathologically proven Parkinson disease

Adult-onset glycogen storage disease type II: phenotypic and allelic heterogeneity in German patients

Lack of association between apolipoprotein E genotype and sporadic amyotrophic lateral sclerosis

Chromosomal localization of two genes underlying late-infantile neuronal ceroid lipofuscinosis

Histopathology and APOE genotype of the first Alzheimer disease patient, Auguste D.

Neurogenetics : Volume 1, Issue 2, November 1997

Neurogenetics : Volume 1, Issue 1, May 1997

No genetic association between the LRP receptor and sporadic or late-onset familial Alzheimer disease

Content Provider	Springer Nature Link
Author	Scott, William K. Yamaoka, Larry H. Bass, Meredyth P. Gaskell, P. Craig Conneally, P. Michael Small, Gary W. Farrer, Lindsay A. Auerbach, Sanford A. Saunders, Ann M. Roses, Allen D. Haines, J. L. Pericak Vance, Margaret A.
Copyright Year	1998
Abstract	The low-density lipoprotein receptor-related protein gene (LRP1) is often mentioned as a candidate gene for Alzheimer disease (AD) because of its role as a receptor for apolipoprotein E (apoE), a major genetic risk factor for late-onset familial and sporadic AD. A recent association study of a tetranucleotide repeat polymorphism located 5′ to the LRP1 gene detected an increase in the 87 base pair allele in AD cases compared to unaffected controls. Additionally, an independent study involving a genomic screen for genes associated with late-onset AD identified a region as a possible location of a late-onset AD gene on chromosome 12p between D12S373 and D12S390, about 10 cM proximal to LRP1. We examined 144 late-onset multiplex AD families, 436 sporadic AD cases, and 240 controls and found no evidence of linkage or association of LRP1 and AD. Our data indicate that genetic variation of the LRP1 gene is not a major risk factor in the etiology of AD.
Starting Page	179
Ending Page	183
Page Count	5
File Format	PDF
ISSN	13646745
Journal	Neurogenetics
Volume Number	1
Issue Number	3
Language	English
Publisher	Springer-Verlag
Publisher Date	1998-03-24
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Genetics Cellular and Molecular Neuroscience Genetics (clinical)

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Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease

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No genetic association between the LRP receptor and sporadic or late-onset familial Alzheimer disease

Similar Documents

No association between the HLA-A2 allele and Alzheimer disease

Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease

Association between coding variability in the LRP gene and the risk of late-onset Alzheimer’s disease

Association of late-onset Alzheimer disease with a genotype of PLAU, the gene encoding urokinase-type plasminogen activator on chromosome 10q22.2

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No genetic association between the LRP receptor and sporadic or late-onset familial Alzheimer disease