NDLI: Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease

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Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease

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Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease

Content Provider	Springer Nature Link
Author	Blomqvist, Mia E. L. Silburn, Peter A. Buchanan, Daniel D. Andreasen, Niels Blenw, Kaj Pedersen, Nancy L. Brookes, Anthony J. Mellick, George D. Prince, Jonathan A.
Copyright Year	2004
Abstract	We recently reported that a linkage disequilibrium (LD) block on chromosome 10q encompassing the gene encoding insulin-degrading enzyme (IDE) harbors sequence variants that associate with Alzheimer disease (AD). Evidence also indicated effects upon a number of quantitative indices of AD severity, including age-at-onset (AAO). Since linkage of this immediate region to AAO has been shown in both AD and Parkinson disease (PD), we have explored the possibility that polymorphism within this LD block might also influence PD. Utilizing single nucleotide polymorphisms that delineate common haplotypes from this region, we observed significant evidence of association with AAO in an Australian PD case-control sample. Analyses were complemented with AAO data from two independent Swedish AD case samples, for which previously reported findings were replicated. Results were consistent between AD and PD, suggesting the presence of equivalent detrimental and protective alleles. These data highlight a genomic region in the proximity of IDE that may contribute to AD and PD in a similar manner.
Starting Page	115
Ending Page	119
Page Count	5
File Format	PDF
ISSN	13646745
Journal	Neurogenetics
Volume Number	5
Issue Number	2
e-ISSN	13646753
Language	English
Publisher	Springer-Verlag
Publisher Date	2004-04-16
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	IDE Age at onset Linkage disequilibrium Alzheimer disease Parkinson disease
Content Type	Text
Resource Type	Article
Subject	Genetics Cellular and Molecular Neuroscience Genetics (clinical)

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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