NDLI: Genetic susceptibility to MS: a second stage analysis in Canadian MS families

Content Provider	Springer Nature Link
Author	Dyment, David A. Willer, Cristen J. Scott, Beverly Armstrong, Holly Ligers, Arturs Hillert, Jan Paty, Donald W. Hashimoto, Stanley Devonshire, Virginia Hooge, John Kastrukoff, Lorne Oger, Joel Metz, Luanne Warren, Sharon Hader, Walter Power, Cristopher Auty, Anthony Nath, Avindra Nelson, Robert Freedman, Mark Brunet, Donald Paulseth, John E. Rice, George O'Conr, Paul Duquette, Pierre Lapierre, Yves Francis, Gordon Bouchard, Jean Pierre Murray, John T. Bhan, Virender Maxner, Charles Pryse Phillips, William Stefanelli, Mark Sadovnick, Dessa A. Risch, Neil Ebers, George C.
Copyright Year	2001
Abstract	Four published genome screens have identified a number of markers with increased sharing in multiple sclerosis (MS) families, although none has reached statistical significance. One hundred and five markers previously identified as showing increased sharing in Canadian, British, Finnish, and American genome screens were genotyped in 219 sibling pairs ascertained from the database of the Canadian Collaborative Project on Genetic Susceptibility to MS (CCPGSMS). No markers examined met criteria for significant linkage. Markers located at 5p14 and 17q22 were analyzed in a total of 333 sibling pairs and attained mlod scores of 2.27 and 1.14, respectively. The known HLA Class II DRB1 association with MS was confirmed (P<0.0001). Significant transmission disequilibrium was also observed for D17S789 at 17q22 (P=0.0015). This study highlights the difficulty of searching for genes with only mild-to-moderate effects on susceptibility, although large effects of specific loci may still be present in individual families. Future progress in the genetics of this complex trait may be helped by (1) focussing on more ethnically homogeneous samples, (2) using an increased number of MS families, and (3) using transmission disequilibrium analysis in candidate regions rather than the affected relative pair linkage analysis.
Starting Page	145
Ending Page	151
Page Count	7
File Format	PDF
ISSN	13646745
Journal	Neurogenetics
Volume Number	3
Issue Number	3
Language	English
Publisher	Springer-Verlag
Publisher Date	2001-05-16
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neurosciences Human Genetics Molecular Medicine
Content Type	Text
Resource Type	Article
Subject	Genetics Cellular and Molecular Neuroscience Genetics (clinical)

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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