NDLI: CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations

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An SPG3A whole gene deletion neither co-segregates with disease nor modifies phenotype in a hereditary spastic paraplegia family with a pathogenic SPG4 deletion

Acknowledgement to Referees 2006/2007

Neurogenetics : Volume 8, Issue 3, August 2007

Neurogenetics : Volume 8, Issue 2, April 2007

Neurogenetics : Volume 8, Issue 1, January 2007

Neurogenetics : Volume 7

Neurogenetics : Volume 6

Neurogenetics : Volume 5

Neurogenetics : Volume 4

Neurogenetics : Volume 3

Neurogenetics : Volume 2

Neurogenetics : Volume 1

CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations

Content Provider	Springer Nature Link
Author	Voss, Katrin Stahl, Sonja Schleider, Elisa Ullrich, Sybille Nickel, Joachim Mueller, Thomas D. Felbor, Ute
Copyright Year	2007
Abstract	Individuals carrying a mutation in one of the three cerebral cavernous malformation genes (CCM1/KRIT1, CCM2, CCM3) cannot be clinically distinguished, raising the possibility that they act within common molecular pathways. In this study, we demonstrate that CCM3 (PDCD10) coprecipitates and colocalizes with CCM2. We also show that CCM3 directly binds to serine/threonine kinase 25 (STK25, YSK1, SOK1) and the phosphatase domain of Fas-associated phosphatase-1 (FAP-1, PTPN13, PTP-Bas, PTP-BL). CCM3 is phosphorylated by STK25 but not by its other Yeast-Two hybrid interactor STK24, whereas the C-terminal catalytic domain of FAP-1 dephosphorylates CCM3. Finally, our experiments reveal that STK25 forms a protein complex with CCM2. Thus, our data link two proteins of unknown function, CCM3 and STK25, with CCM2, which is part of signaling pathways essential for vascular development and CCM pathogenesis.
Starting Page	249
Ending Page	256
Page Count	8
File Format	PDF
ISSN	13646745
Journal	Neurogenetics
Volume Number	8
Issue Number	4
e-ISSN	13646753
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-07-27
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cerebral cavernous malformation CCM3 CCM2 STK25 FAP-1 Molecular Medicine Human Genetics Neurosciences
Content Type	Text
Resource Type	Article
Subject	Genetics Cellular and Molecular Neuroscience Genetics (clinical)

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Cerebral Cavernous Malformations: Review of the Genetic and Protein–Protein Interactions Resulting in Disease Pathogenesis

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CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations

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CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations