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Specific mutations in the HEXA gene among Iraqi Jewish Tay-Sachs disease carriers: dating of founder ancestor

Content Provider	Springer Nature Link
Author	Karpati, Mazal Gazit, Ephraim Goldman, Boleslaw Frisch, Amos Colombo, Roberto Peleg, Leah
Copyright Year	2004
Abstract	The incidence of Tay-Sachs disease (TSD) carriers, as defined by enzyme assay, is 1:29 among Ashkenazi Jews and 1:110 among Moroccan Jews. An elevated carrier frequency of 1:140 was also observed in the Iraqi Jews (IJ), while in other Israeli populations the world’s pan-ethnic frequency of approximately 1:280 has been found. Recently a novel mutation, G749T, has been reported in 38.7% of the IJ carriers (24/62). Here we report a second novel HEXA mutation specific to the IJ TDS carriers: a substitution of cytosine 1351 by guanosine (C1351G), resulting in the change of leucine to valine in position 451. This mutation was found in 33.9% (21/62) of the carriers and in none of 100 non-carrier IJ. In addition to the two specific mutations, 14.5% (9/62) of the IJ carriers bear a known “Jewish” mutation (Ashkenazi or Moroccan) and 11.3% (7/62) carry a known “non-Jewish” mutation. In 1 DNA sample no mutation has yet been detected. To investigate the genetic history of the IJ-specific mutations (C1351G and G749T), the allelic distribution of four polymorphic markers (D15S131, D15S1025, D15S981, D15S1050) was analyzed in IJ heterozygotes and ethnically matched controls. Based on linkage disequilibrium, recombination factor (θ) between the markers and mutated loci, and the population growth correction, we deduced that G749T occurred in a founder ancestor 44.8±14.2 generations (g) ago [95% confidence interval (CI) 17.0–72.6 g] and C1351G arose 80.4±35.9 g ago (95% CI 44.5–116.3 g). Thus, the estimated dates for introduction of mutations are: 626±426 A.D. (200–1052 A.D.) for G749T and 442±1077 B.C. (1519 B.C. to 635 A.D.) for C1351G.
Starting Page	35
Ending Page	40
Page Count	6
File Format	PDF
ISSN	13646745
Journal	Neurogenetics
Volume Number	5
Issue Number	1
e-ISSN	13646753
Language	English
Publisher	Springer-Verlag
Publisher Date	2003-11-27
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	HEXA gene Tay-Sachs disease Iraqi Jews Founder effect Linkage disequilibrium
Content Type	Text
Resource Type	Article
Subject	Genetics Cellular and Molecular Neuroscience Genetics (clinical)

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