NDLI: Granular dynamics simulations of the effect of grain size dispersity on uniaxially compacted powder blends

Content Provider	Springer Nature Link
Author	Dutt, Meenakshi Elliott, James A.
Copyright Year	2013
Abstract	We investigate, via granular dynamics simulations, the influence of particle size dispersity on the packing characteristics of uniaxially compacted pharmaceutical blends. We employ reduced models of representative pharmaceutical excipient blends comprised of one, two, four and six components of different size, where the grain size in each component is distinct. We investigate the particle dynamics and reorganization during the compaction phase after the blend has been poured into a tablet die. For small strains, we demonstrate the packing fraction of the powder blends to scale linearly with the axial strain. We do not observe any significant variation in the stress response of the blend with particle size dispersity at small strains, but the mixtures with greater particle size dispersity remain compactible up to higher strains than the less polydisperse mixtures.
Starting Page	243
Ending Page	248
Page Count	6
File Format	PDF
ISSN	14345021
Journal	Granular Matter
Volume Number	16
Issue Number	2
e-ISSN	14347636
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2013-12-05
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discrete element modeling Size dispersity Particle packing Soft and Granular Matter, Complex Fluids and Microfluidics Engineering Fluid Dynamics Materials Science Geoengineering, Foundations, Hydraulics Industrial Chemistry/Chemical Engineering Engineering Thermodynamics, Heat and Mass Transfer
Content Type	Text
Resource Type	Article
Subject	Physics and Astronomy Mechanics of Materials Materials Science

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