NDLI: DEM analysis of particle adhesion during powder mixing for dry powder inhaler formulation development

Content Provider	Springer Nature Link
Author	Yang, Jiecheng Wu, Chuan Yu Adams, Michael
Copyright Year	2013
Abstract	Understanding the adhesive interactions between active pharmaceutical ingredient (API) particles and carrier particles in dry powder inhalers (DPIs) is critical for the development of formulations and process design. In the current study, a discrete element method, which accounts for particle adhesion, is employed to investigate the attachment processes in DPIs. A critical velocity criterion is proposed to determine the lowest impact velocity at which two elastic autoadhesive spherical particles will rebound from each other during impact. Furthermore, the process of fine API particles adhering to a large carrier in a vibrating container is investigated. It was found that there are optimal amplitude and frequency for the vibration velocity that can maximise the number of particles contacting with the carrier (i.e. the contact number). The impact number and detachment number during the vibration process both increase with increasing vibration amplitude and frequency while the sticking efficiency decreases as the amplitude and frequency are increased.
Starting Page	417
Ending Page	426
Page Count	10
File Format	PDF
ISSN	14345021
Journal	Granular Matter
Volume Number	15
Issue Number	4
e-ISSN	14347636
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2013-03-22
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Adhesion Discrete element method Attachment Mixing Granular materials Soft and Granular Matter, Complex Fluids and Microfluidics Engineering Fluid Dynamics Materials Science Geoengineering, Foundations, Hydraulics Industrial Chemistry/Chemical Engineering Engineering Thermodynamics, Heat and Mass Transfer
Content Type	Text
Resource Type	Article
Subject	Physics and Astronomy Mechanics of Materials Materials Science

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