NDLI: Molecular insights into evolution

Content Provider	Springer Nature Link
Author	Schuster, Peter
Copyright Year	1999
Abstract	The evolution of ribonucleic acid (RNA) molecules in the test tube provides a possible way to study evolutionary optimization and adaptation to the environment on time scales accessible to human observers. Diversity of genotypes, however, is prohibitive for a complete experimental recording of the process at the molecular level. The number of RNA sequences and structures is too large to be determined by means of currently available techniques. Computer simulation, on the other hand, is able to handle large numbers of individual sequences and has no major problem with data retrieval. However, it can deal only with simplified relations between genotypes and phenotypes, i.e., RNA sequences and structures, respectively. Based on a coarse-grained notion of structure, as represented by RNA secondary structures, for example, a comprehensive model of evolution has been developed that allows as to follow optimization at full molecular resolution. This model describes the course of in vitro selection experiments, and provides a straightforward explanation for the occurrence of steps observed in evolution. It initiated the development of new mathematical concepts which analyse evolution as a complex process viewed simultaneously in concentration space, sequence space, and shape space.
Starting Page	19
Ending Page	23
Page Count	5
File Format	PDF
ISSN	14335298
Journal	Artificial Life and Robotics
Volume Number	3
Issue Number	1
e-ISSN	16147456
Language	English
Publisher	Springer-Verlag
Publisher Date	1999-01-01
Publisher Place	Tokyo
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Molecular evolution Neutral networks Punctuation RNA secondary structures Selective neutrality Computation by Abstract Devices Artificial Intelligence (incl. Robotics) Automation and Robotics
Content Type	Text
Resource Type	Article
Subject	Artificial Intelligence Biochemistry, Genetics and Molecular Biology

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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