NDLI: Simultaneous and sensitive determination of procaine and its metabolite for pharmaceutical quality control and pharmacokinetic research by using a graphite paste electrode

Content Provider	Springer Nature Link
Author	Liu, Ai Lin Wang, Jia Dong Chen, Wei Xia, Xing Hua Chen, Yuan Zhong Lin, Xin Hua
Copyright Year	2011
Abstract	A simple, rapid, sensitive, and accurate method for simultaneous electrochemical determination of procaine and its metabolite (p-aminobenzoic acid, PABA) for pharmaceutical quality control and pharmacokinetic research was developed using a graphite paste electrode. The differential pulse voltammetric results revealed that procaine and p-aminobenzoic acid, respectively, showed well-defined anodic oxidation peaks on a carbon paste electrode with a current peak separation of 155 mV at a scan rate of 100 mV s−1. This well separation of the current peaks for these two compounds in voltammetry enables us to simultaneously determine them. Good linearity (r > 0.998) between oxidation peak current and concentration was obtained in the range of 5.0 × 10−7–5.0 × 10−5 M for procaine and 5.0 × 10−7–2.0 × 10−5 M for PABA in pH 4.50 acetate buffer solution. The detection limit for both analytes is 5 × 10−8 M (S/N = 3:1). The present voltammetric method has been successfully used to determine trace p-aminobenzoic acid in procaine hydrochloride injection and procaine in plasma with a linear relationship of current to its concentration ranging from 1.0 × 10−6 to 5.0 × 10−5 M (correlation coefficient of 0.9981) with a low detection limit of 5.0 × 10−7 M (S/N = 3:1). This validated method is promising to the study of pharmacokinetics in Sprague–Dawley rat and rabbit plasma after an intravenous administration of procaine hydrochloride injection.
Starting Page	1343
Ending Page	1351
Page Count	9
File Format	PDF
ISSN	14328488
Journal	Journal of Solid State Electrochemistry
Volume Number	16
Issue Number	4
e-ISSN	14330768
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-08-25
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Procaine p-Aminobenzoic acid Graphite paste electrode Rat plasma Pharmacokinetics Electrochemical analysis Physical Chemistry Characterization and Evaluation of Materials Energy Storage Condensed Matter Physics Analytical Chemistry Electrochemistry
Content Type	Text
Resource Type	Article
Subject	Condensed Matter Physics Materials Science Electrical and Electronic Engineering Electrochemistry

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