NDLI: Fabrication of an interferon-gamma-based ITO detector for latent tuberculosis diagnosis with high stability and lower cost

Content Provider	Springer Nature Link
Author	Zhang, Yaru Yan, Yuqi Zhang, Bin Zhu, Wenguang He, Yanjin Huang, Hongxing Li, Jiong Jiang, Zhenyou Tan, Shaozao Cai, Xiang
Copyright Year	2015
Abstract	Interferon-gamma (IFN-γ) released by T cells performs very important roles in latent diagnosis of Mycobacterium tuberculosis (MTB) infections and control of tuberculosis. In this work, a multilayer screen printing indium tin oxide (ITO) detector modified with a self-assembled graphene/chitosan (Gr-Chit) composite film followed by glutathione-modified gold nanoparticles (GSH-AuNPs), antibodies, and antigens was fabricated for highly sensitive and rapid detection of IFN-γ. The formation of the antibody-antigen complex at the electrode surface causes the impedance to increase. Under optimum conditions, the relative increased differential pulse voltammetry (DPV) peak current values are proportional to the logarithmic value of IFN-γ concentrations in a wide range of 5 to 4000 pg/mL with a low detection limit of 0.5 pg/mL (S/N = 3). The resulting IFN-γ immunosensor shows excellent detection reproducibility, good specificity, and stability. In addition, for the detection of clinical serum samples, it is well consistent with the standard enzyme-linked immunosorbent assay (ELISA) tests. Compared to the expensive glassy carbon electrode, the ITO detector can act as a disposable electrode in clinical detection due to its low cost. This study provides a lower cost, simple, and highly sensitive approach for potential application in early diagnosis of MTB infections and control of tuberculosis. Graphical Abstract ᅟ
Starting Page	3111
Ending Page	3119
Page Count	9
File Format	PDF
ISSN	14328488
Journal	Journal of Solid State Electrochemistry
Volume Number	19
Issue Number	10
e-ISSN	14330768
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2015-07-02
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Graphene Chitosan Gold nanoparticles Glutathione Interferon-gamma Electrode Physical Chemistry Electrochemistry Energy Storage Characterization and Evaluation of Materials Analytical Chemistry Condensed Matter Physics
Content Type	Text
Resource Type	Article
Subject	Condensed Matter Physics Materials Science Electrical and Electronic Engineering Electrochemistry

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